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Egyptian Journal of Medical Human Genetics

Table 6 Association between different study parameters and gene polymorphism for VDR at rs2228570 (FokI) in CVD patients without and with diabetes

From: Vitamin D levels and vitamin D receptor genetic variants in Egyptian cardiovascular disease patients with and without diabetes

Groups and genotypes

Variables

CVD without T2D (n=124)

CC

n=44

CT

n=56

TT

n=24

Kruskal-

Wallis

P value

CT+TT

n=80

CT+TT/CC

BMI (kg/m2)

28.8 (27.4-33.2)

29.6 (28.3-32.8)

32.8 (30.9-37.1)

˂0.001

31.2 (28.5-33.9)

˂0.05

SBP (mmHg)

130 (120-140)

140 (130-150)

140 (130-140)

˂0.001

140 (130-150)

˂0.001

DSP (mmHg)

80 (80-90)

85 (80-97.5)

80 (80-90)

˂0.05

80 (80-90)

˂0.05

FBG (mg/dl)

85.7 (81.8-90.6)

90.4 (83.4-96.6)

110.3 (86.5-115.3)

˂0.001

93 (84.1-104.9)

˂0.01

Insulin (흁/l)

11.5 (9.4-15.4)

16.5 (9.5-25.1)

10.1 (6.1-38.8)

0.11

15.8 (8.8--26.5)

˂0.05

HOMA-IR

2.3 (1.9-3.2)

3.5 (2-5.9)

2.8 (1.6-9.4)

˂0.05

3.3 (2-6.5)

˂0.05

TC (mg/dl)

197.6 (185.6-203.3)

206.9 (177.3-220.1)

226.6 (201.3-254.8)

˂0.001

211 (181.5-225.3)

˂0.01

TG (mg/dl)

126.5 (97-145)

145.6 (123.7-158)

167 (146.4-180.2)

˂0.001

152.2 (130.1-165.6)

˂0.01

HDL-C (mg/dl)

48.75 (40-56.4)

42.1 (34.2-45.6)

36 (24-54.8)

˂0.05

40.7 (32.4-48.2)

˂0.01

LDL-C (mg/dL)

124.2 (113.2-144.3)

136.1 (115.8-144.3)

141.4 (116.5-191.3)

0.054

137.5 (115.9-150.5)

0.57

Vit.D (ng/ml)

20.6 (18.1-25.5)

17 (13.7-21.1)

8.8 (7.2-10.3)

˂0.001

16.3 (10-19.2)

˂0.001

Groups and genotypes

Variables

CVD with T2D (n=120)

CC

n=36

CT

n=58

TT

n=26

Kruskal-Wallis

P value

CT+TT

n=84

CT+TT/CC

BMI (kg/m2)

28.5 (25-30.4)

30.8 (27.6-33.2)

31 (28.8-33.4)

˂0.01

30.8 (28.1-33.2)

˂0.01

SBP (mmHg)

140 (130-140)

130 (117.5-150)

140 (130-150)

0.62

140 (120-150)

0.67

DSP(mmHg)

80 (80-90)

90 (77.5-100)

90 (80-90)

0.7

90 (80-90)

0.5

FBG (mg/dl)

154.2 (137.4-180)

196.7 (181.4-241.8)

210.6 (168.5-226.9)

˂0.001

196.7 (178.4-240.7)

˂0.001

Insulin (흁/l)

23.3 (14.6-28.5)

28.5 (19.5-42.6)

30.4 (16-63.4)

0.07

29.4 (18.6-53.2)

˂0.05

HOMA-IR

9.7 (5.7-13.1)

12.8 (9.42-26)

14.2 (7.4-31.1)

˂0.01

13.2 (8.1-29.4)

˂0.01

TC (mg/dl)

191.6 (184.3-205.9)

200.5 (197.2-216.2)

259.5 (202.5-271.8)

˂0.001

204.9 (189.2-250.4)

˂0.001

TG (mg/dl)

134.9 (100.7-156)

140.6 (128.5-167.6)

176.5 (155.6-198.7)

˂0.001

151.7 (136.8-167.5)

˂0.01

HDL-C (mg/dl)

41.6 (38.2-55.2)

36.8 (30.3-40.6)

30.5 (24.4-37.2)

˂0.001

35.5 (28.6-40.5)

˂0.01

LDL-C (mg/dL)

125.7 (110.3-142.3)

136.8 (126.5-152.6)

179.8 (141-204.4)

˂0.001

140.9 (129.1-179.7)

˂0.001

Vit.D (ng/ml)

16.9 (15.2-18.8)

12.8 (10.5-14.5)

6.5 (4.6-9.1)

˂0.001

12.5 (8-14.2)

˂0.001

  1. Data were expressed as median (interquartile range, IQR: 25th-75th quartile) and compared using the non-parametric Kruskal-Wallis test
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