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Egyptian Journal of Medical Human Genetics

Table 7 Association between different study parameters and different VDR at rs1544410 A >G (BsmI) genotypes in CVD patients without and with diabetes

From: Vitamin D levels and vitamin D receptor genetic variants in Egyptian cardiovascular disease patients with and without diabetes

Groups and genotypes

Variables

CVD without T2D (n=124)

AA

n=16

AG

n=44

GG

n=64

Kruskal-Wallis

P value

AG+GG

n=108

AG+GG/AA

BMI (kg/m2)

28.2 (26.9-30)

29.2 (27.1-30.7)

32.5 (29.3-34.5)

˂0.001

31.2 (28.5-33.9)

˂0.01

SBP (mmHg)

130 (112.5-130)

130 (120-140)

140(130-150)

˂0.01

140 (130-150)

˂0.05

DSP (mmHg)

70 (70-87.5)

80 (80-90)

80 (80-90)

˂0.01

80 (80-90)

˂0.01

FBG (mg/dl)

88.8 (82-100.6)

85.3 (79.9-88.5)

95.2 (88.8-106.8)

˂0.001

93 (84.1-104.9)

0.85

Insulin (흁/l)

8.8 (7.4-17)

12.2 (10-15.4)

18.1 (9.4-28)

˂0.05

15.8 (8.8-26.5)

˂0.05

HOMA-IR

1.9 (1.5-3.5)

2.4 (2-3.3)

3.9 (2-6.8)

˂0.05

3.3 (2-6.5)

˂0.05

TC (mg/dl)

185.6 (177.3-195.3)

198.8 (189.4-205.9)

219.6 (198.8-225.3)

˂0.001

211 (181.5-225.3)

˂0.01

TG (mg/dl)

101.4 (83.1-159.4)

124.8 (97-140.6)

157.5 (140.9-169.2)

˂0.001

152.2 (130.1-165.6)

˂0.05

HDL-C (mg/dl)

57.7 (50.3-63.3)

46.4 (34.8-55.2)

38.2 (31.4-44.7)

˂0.001

40.7 (32.4-48.2)

˂0.001

LDL-C (mg/dL)

108.4 (96.9-124.3)

125.3 (116.9-140.4)

140.3 (116.5-156.9)

˂0.001

137.5 (115.9-150.5)

˂0.001

Vit.D (ng/ml)

25.7 (21.4-27.4)

20.1 (17.8-22.4)

12.9 (9.7-16.9)

˂0.001

16.3 (10-19.2)

˂0.001

Groups andgenotypes

Variables

CVD with T2D (n=120)

AA

n=10

AG

n=35

GG

n=75

Kruskal-Wallis

P value

AG+GG

n=110

AG+GG/AA

BMI (kg/m2)

26.1 (22.9-31.5)

29.3 (26.2-30.8)

30.4 (27.7-33.2)

0.07

29.4 (27.6-33.2)

˂0.05

SBP (mmHg)

130 (120-145)

140 (120-150)

140 (130-150)

0.062

140 (130-150)

0.45

DSP(mmHg)

80 (75-90)

90 (80-100)

90 (80-90)

0.12

90 (80-90)

0.15

FBG (mg/dl)

150 (128.9-209.1)

159.5 (139.1-182.4)

196.3 (178.1-245.5)

˂0.001

189.4 (159.5-239)

˂0.05

Insulin (훍/l)

14.2 (8.4-31.9)

21 (13.4-31.3)

28.5 (19.6-54.4)

˂0.01

27.4 (17.4-47.8)

˂0.05

HOMA-IR

7.6 (3.6-10.4)

7.4 (5.7-13.1)

13.6 (10-34.1)

˂0.001

12.6 (7.1-25.1)

˂0.01

TC (mg/dl)

202.1 (171.1-204 )

195.2 (184.8-205.9)

207.5 (198.2-254.4)

˂0.001

200.5 (192.8-223.4)

0.1

TG (mg/dl)

137.5 (96.9-153.2)

156 (130.6-168.9)

147.8 (124.8-178.7)

0.169

148.6 (130-175.3)

0.07

HDL-C (mg/dl)

53 (44.2-58.1)

42.3 (36.8-55.2)

33.2 (27.1-38.8)

˂0.001

36.7 (28.6-41.2)

˂0.001

LDL-C (mg/dL)

126 (94-128.3)

124.1 (101-142.3)

144.2 (132-180)

˂0.001

139.5 (125.9-166.2)

˂0.05

Vit.D (ng/ml)

18.1 (14.4-22.2)

15.2 (13.4-17.8)

12.3 (7.8-14.5)

˂0.001

12.8 (10-15.8)

˂0.01

  1. Data were expressed as median (interquartile range, IQR: 25th-75th quartile) and compared using the non-parametric Kruskal-Wallis test
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