Class | Properties | Cromolyn Sodium | Catechin | Crinamine | Epicatechin | Nimbandiol | Nimbinene | Kaempferol | Nimbin | Ellagic acid | Lycorine | Quercetin |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Absorption | BBB | Yes | No | Yes | No | Yes | Yes | No | Yes | No | Yes | No |
Caco-2 permeability | No | No | Yes | No | No | No | No | No | No | Yes | No | |
GIA | High | High | High | High | High | High | High | High | High | High | High | |
Pgp-inhibitor | Yes | No | No | No | Yes | Yes | No | Yes | No | No | No | |
Pgp-substrate | No | No | No | Yes | Yes | Yes | No | Yes | No | No | Yes | |
Distribution | PPB | 50.8% (Moderate) | 112.0% (high) | 86.7% (high) | 112.0% (high) | 85.1% (high) | 76.0% (slightly high) | 106.1% (high) | 78.8% (slightly high) | 99.3% (high) | 78.5% (slightly high) | 117.5% (high) |
Sub-cellular localization | Mitochondria | Mitochondria | Lysosomes | Mitochondria | Mitochondria | Mitochondria | Mitochondria | Mitochondria | Mitochondria | Mitochondria | Mitochondria | |
Metabolism | CYP450 1A2 inhibition | No | No | No | No | No | No | Yes | No | No | Yes | Yes |
CYP450 3A4 inhibition | No | No | No | No | No | Yes | Yes | Yes | No | No | Yes | |
CYP450 3A4 substrate | No | No | Yes | No | Yes | Yes | Yes | Yes | No | Yes | No | |
CYP450 2C9 inhibition | No | No | No | No | No | No | Yes | No | No | No | No | |
CYP450 2C9 substrate | No | No | No | No | No | No | No | No | No | No | No | |
CYP450 2C19 inhibition | No | No | No | No | No | No | Yes | No | No | No | No | |
CYP450 2D6 inhibition | No | No | Yes | No | No | No | No | No | No | Yes | Yes | |
CYP450 2D6 substrate | No | Yes | Yes | Yes | No | No | No | No | No | Yes | No | |
UGT catalyzed | No | Yes | No | Yes | Yes | No | Yes | No | Yes | Yes | Yes | |
Toxicity | Acute oral toxicity | Class iii | Class iv | Class iii | Class iv | Class iii | Class iii | Class ii | Class iii | Class ii | Class iii | Class ii |
hERG inhibitor | No | No | No | No | Yes | Yes | No | Yes | No | No | No | |
Human hepatotoxicity | Yes | No | No | No | Yes | Yes | Yes | Yes | Yes | No | No | |
Ames mutagenicity | No | Yes | No | Yes | No | No | Yes | No | No | Yes | No | |
Carcinogens | No | No | No | No | No | No | No | No | No | No | No |