Table 3 ADME/T properties of curcumin I (PubChem CID: 969516), curcumin II (PubChem CID: 5469424) and curcumin III (PubChem CID: 5315472). BBB+: capable of penetrating the blood-brain barrier (BBB); HIA+: absorbed in human intestinal tissue; Caco-2+: permeable through the membrane of Caco-2 cell lines; CYP450: cytochrome P450
Properties | Curcumin I | Curcumin II | Curcumin III |
|---|---|---|---|
Blood-brain barrier | BBB+ | BBB+ | BBB+ |
Human intestinal absorption | HIA+ | HIA+ | HIA+ |
Caco-2 Permeability | Caco2+ | Caco2+ | Caco2+ |
P-Glycoprotein substrate | Substrate | Substrate | Non-substrate |
CYP450 2C9 substrate | Non-substrate | Non-substrate | Non-substrate |
CYP450 2D6 substrate | Non-substrate | Non-substrate | Non-substrate |
CYP450 3A4 substrate | Non-substrate | Non-substrate | Non-substrate |
CYP450 1A2 inhibitor | Inhibitor | Inhibitor | Inhibitor |
CYP450 2C9 inhibitor | Inhibitor | Inhibitor | Inhibitor |
CYP450 2D6 inhibitor | Inhibitor | Non-inhibitor | Non-inhibitor |
CYP450 2C19 inhibitor | Inhibitor | Inhibitor | Inhibitor |
CYP450 3A4 inhibitor | Non-inhibitor | Non-inhibitor | Inhibitor |
CYP inhibitory promiscuity | High CYP inhibitory promiscuity | High CYP inhibitory promiscuity | Low CYP inhibitory promiscuity |
AMES toxicity | Non AMES toxic | Non AMES toxic | Non AMES toxic |
Carcinogens | Non-carcinogens | Non-carcinogens | Non-carcinogens |
Biodegradation | Not ready biodegradable | Not ready biodegradable | Not ready biodegradable |
Acute oral toxicity | III | III | III |