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Table 4 Pharmacological activities of curcumin I (PubChem CID: 969516), curcumin II (PubChem CID: 5469424), and curcumin III (PubChem CID: 5315472). When Pa > 0.7: compound is very likely to exhibit the activity; when 0.7 > Pa > 0.5: compound is likely to exhibit the activity; when Pa < 0.5: compound is less likely to exhibit the activity

From: In silico investigations on curcuminoids from Curcuma longa as positive regulators of the Wnt/β-catenin signaling pathway in wound healing

Sl. no.

Biological activity

Curcumin I

Curcumin II

Curcumin III

Pa

Pi

Pa

Pi

Pa

Pi

1

Antiallergic

0.435

0.043

0.408

0.05

0.251

0.129

2

Antiinflammatory

0.677

0.019

0.667

0.02

0.704

0.015

3

Antimutagenic

0.814

0.004

0.834

0.003

0.79

0.004

4

Apoptosis agonist

0.803

0.008

0.861

0.005

0.871

0.005

5

Antiulcerative

0.651

0.007

0.65

0.007

0.633

0.009

6

Antioxidant

0.61

0.004

0.624

0.004

0.637

0.004

7

Caspase 3 stimulant

0.747

0.009

0.719

0.01

0.492

0.029

8

Chemopreventive

0.692

0.007

0.718

0.006

0.576

0.011

9

Carminative

0.833

0.003

0.81

0.004

0.822

0.003

10

DNA ligase (ATP) inhibitor

0.314

0.04

0.326

0.036

0.364

0.024

11

Free radical scavenger

0.766

0.003

0.785

0.003

0.67

0.004

12

Fibrinolytic

0.731

0.013

0.735

0.012

0.717

0.017

13

Gluconate 2-dehydrogenase inhibitor

0.833

0.01

0.822

0.012

0.836

0.009

14

Hepatoprotectant

0.469

0.023

0.656

0.009

0.578

0.014

15

HMOX1 expression enhancer

0.826

0.003

0.854

0.003

0.858

0.003

16

Membrane permeability inhibitor

0.724

0.029

0.736

0.025

0.721

0.03

17

Prostate cancer treatment

0.554

0.006

0.555

0.006

0.573

0.005

18

Proliferative disease treatment

0.558

0.014

0.59

0.011

0.553

0.014

19

Reductant

0.864

0.003

0.884

0.003

0.908

0.003

20

Radioprotector

0.559

0.019

0.561

0.019

0.566

0.019

21

Sigma receptor agonist

0.505

0.024

0.521

0.022

0.488

0.027

22

Sugar-phosphatase inhibitor

0.593

0.057

0.555

0.067

0.782

0.019

23

TNF expression inhibitor

0.764

0.004

0.901

0.002

0.825

0.003

24

UDP-glucuronosyltransferase substrate

0.747

0.011

0.775

0.009

0.739

0.012

25

Vasoprotector

0.678

0.012

0.62

0.017

0.654

0.014