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Table 3 DNA methylation percentage of ATM and SCGB3A1 promoters in the studied groups

From: SCGB3A1 gene DNA methylation status is associated with breast cancer in Egyptian female patients

 

Tumor group (n = 50)

Normal group (n = 50)

P

Mean ± SD

Median (IQR)

Mean ± SD

Median (IQR)

ATM (%)

 CpG_1

2.9 ± 1.8

2 (3)

3.4 ± 2.2

3 (3)

0.194

 CpG_2

8.3 ± 4

7.5 (7)

9.6 ± 4.3

10 (6)

0.356

 CpG_3

11.4 ± 5.2

10 (9)

12 ± 4.8

12.5 (8)

0.550

 CpG_4

4.6 ± 2.2

5 (3)

5.1 ± 2.5

4.5 (4)

0.495

 Average CpG sites

6.8 ± 2.8

6.3 (4.8)

7.5 ± 3

8.4 (5.3)

0.315

SCGB3A1 (%)

 CpG_1

32.3 ± 20.7

22.5 (37)

23.9 ± 17.1

22.5 (22)

0.001*

 CpG_2

78.6 ± 23.5

89.5 (47)

69.9 ± 24.6

72.5 (39)

0.010*

 CpG_3

55.1 ± 24.8

49.5 (49)

48 ± 22.8

45 (33)

0.012*

 CpG_4

29.1 ± 14.9

24 (29)

20 ± 15.3

20 (23)

< 0.001*

 Average CpG sites

48.8 ± 16.6

49.3 (26.5)

40.4 ± 16.3

43.4 (27.8)

0.001*

  1. P value, compares the studied groups using Wilcoxon signed ranks; *, Statistical significance at P ≤ 0.05; SD standard deviation, IQR interquartile range. CpG_1, CpG_2, CpG_3, and CpG_4 stand for the four CpG sites studied in each assay