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Table 3 DNA methylation percentage of ATM and SCGB3A1 promoters in the studied groups

From: SCGB3A1 gene DNA methylation status is associated with breast cancer in Egyptian female patients

  Tumor group (n = 50) Normal group (n = 50) P
Mean ± SD Median (IQR) Mean ± SD Median (IQR)
ATM (%)
 CpG_1 2.9 ± 1.8 2 (3) 3.4 ± 2.2 3 (3) 0.194
 CpG_2 8.3 ± 4 7.5 (7) 9.6 ± 4.3 10 (6) 0.356
 CpG_3 11.4 ± 5.2 10 (9) 12 ± 4.8 12.5 (8) 0.550
 CpG_4 4.6 ± 2.2 5 (3) 5.1 ± 2.5 4.5 (4) 0.495
 Average CpG sites 6.8 ± 2.8 6.3 (4.8) 7.5 ± 3 8.4 (5.3) 0.315
SCGB3A1 (%)
 CpG_1 32.3 ± 20.7 22.5 (37) 23.9 ± 17.1 22.5 (22) 0.001*
 CpG_2 78.6 ± 23.5 89.5 (47) 69.9 ± 24.6 72.5 (39) 0.010*
 CpG_3 55.1 ± 24.8 49.5 (49) 48 ± 22.8 45 (33) 0.012*
 CpG_4 29.1 ± 14.9 24 (29) 20 ± 15.3 20 (23) < 0.001*
 Average CpG sites 48.8 ± 16.6 49.3 (26.5) 40.4 ± 16.3 43.4 (27.8) 0.001*
  1. P value, compares the studied groups using Wilcoxon signed ranks; *, Statistical significance at P ≤ 0.05; SD standard deviation, IQR interquartile range. CpG_1, CpG_2, CpG_3, and CpG_4 stand for the four CpG sites studied in each assay