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Table 4 The associations between ATM and SCGB3A1 methylation frequency and the clinicopathological characteristics of the studied patients

From: SCGB3A1 gene DNA methylation status is associated with breast cancer in Egyptian female patients

  ATM   SCGB3A1  
Variables < 8.4
(n = 29)
≥ 8.4
(n = 21)
P < 43.4
(n = 20)
≥ 43.4
(n = 30)
P
n (%) n (%)   n (%) n (%)  
Age (years)       
 ≤ 50 12 (48) 13 (52) 0.152 9 (36) 16 (64) 0.564
 > 50 17 (68) 8 (32) 11 (44) 14 (56)
Family history       
 Yes 14 (60.9) 9 (39.1) 0.704 11 (47.8) 12 (52.2) 0.297
 No 15 (55.6) 12 (44.4) 9 (33.3) 18 (66.7)
Menstrual history       
 Post menopause 17 (53.1) 15 (46.9) 0.352 12 (37.5) 20 (62.5) 0.630
 Pre menopause 12 (66.7) 6 (33.3) 8 (44.4) 10 (55.6)
Focality       
 Unifocal 24 (54.5) 20 (45.5) 0.380FE 20 (45.5) 24 (54.5) 0.069FE
 Multifocal 5 (83.3) 1 (16.7) 0 (0) 6 (100)
Tumor size (cm)       
 < 2 17 (68) 8 (32) 0.152 7 (28) 18 (72) 0.083
 ≥ 2 12 (48) 13 (52) 13 (52) 12 (48)
Histopathological type       
 IDC 25 (56.8) 19 (43.2) 1.000FE 17 (38.6) 27 (61.4) 0.672FE
 ILC 4 (66.7) 2 (33.3) 3 (50) 3 (50)
Pathological grade       
 Early (GI + GII) 21 (58.3) 15 (41.7) 0.939 12 (33.3) 24 (66.7) 0.123
 Late (GIII) 8 (57.1) 6 (42.9) 8 (57.1) 6 (42.9)
Lymph vascular invasion 27 (62.8) 16 (37.2) 0.115FE 14 (32.6) 29 (67.4) 0.012*FE
LN metastasis 19 (67.9) 9 (32.1) 0.111 7 (25) 21 (75) 0.015*
TNM stage       
 IA 4 (44.4) 5 (55.6) 0.709MC 6 (66.7) 3 (33.3) 0.061MC
 IIA+IIB 19 (59.4) 13 (40.6) 13 (40.6) 19 (59.4)
 III 6 (66.7) 3 (33.3) 1 (11.1) 8 (88.9)
ER positive 21 (58.3) 15 (41.7) 0.939 10 (27.8) 26 (72.2) 0.005*
PR positive 18 (56.3) 14 (43.8) 0.738 9 (28.1) 23 (71.9) 0.022*
HER2/neu positive 22 (56.4) 17 (43.6) 0.741FE 18 (46.2) 21 (53.8) 0.163FE
Molecular type       
 Luminal A 7 (63.6) 4 (36.4) 0.741FE 2 (18.2) 9 (81.8) 0.163FE
 Luminal B 14 (56) 11 (44) 0.774 8 (32) 17 (68) 0.248
 HER2 enriched 8 (57.1) 6 (42.9) 0.939 10 (71.4) 4 (28.6) 0.005*
  1. IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, LN lymph node, TNM tumor-node-metastasis classification system, ER estrogen receptors, PR progesterone receptors, HER2/neu human epidermal growth factor receptor 2
  2. P value, compares the studied groups using χ2 Chi-square test, MC Monte Carlo, FE Fisher’s exact tests; *, statistical significance at P ≤ 0.05