SCGB3A1 gene DNA methylation status is associated with breast cancer in Egyptian female patients

Nomair, Azhar Mohamed; Ahmed, Sanaa Shawky; Mohammed, Ayman Farouk; El Mansy, Hazem; Nomeir, Hanan Mohamed

doi:10.1186/s43042-021-00185-6

Egyptian Journal of Medical Human Genetics

Table 4 The associations between ATM and SCGB3A1 methylation frequency and the clinicopathological characteristics of the studied patients

From: SCGB3A1 gene DNA methylation status is associated with breast cancer in Egyptian female patients

	*ATM*			*SCGB3A1*
Variables	< 8.4 (n = 29)	≥ 8.4 (n = 21)	P	< 43.4 (n = 20)	≥ 43.4 (n = 30)	P
Variables	n (%)	n (%)		n (%)	n (%)
Age (years)
≤ 50	12 (48)	13 (52)	0.152	9 (36)	16 (64)	0.564
> 50	17 (68)	8 (32)	0.152	11 (44)	14 (56)	0.564
Family history
Yes	14 (60.9)	9 (39.1)	0.704	11 (47.8)	12 (52.2)	0.297
No	15 (55.6)	12 (44.4)	0.704	9 (33.3)	18 (66.7)	0.297
Menstrual history
Post menopause	17 (53.1)	15 (46.9)	0.352	12 (37.5)	20 (62.5)	0.630
Pre menopause	12 (66.7)	6 (33.3)	0.352	8 (44.4)	10 (55.6)	0.630
Focality
Unifocal	24 (54.5)	20 (45.5)	0.380^FE	20 (45.5)	24 (54.5)	0.069^FE
Multifocal	5 (83.3)	1 (16.7)	0.380^FE	0 (0)	6 (100)	0.069^FE
Tumor size (cm)
< 2	17 (68)	8 (32)	0.152	7 (28)	18 (72)	0.083
≥ 2	12 (48)	13 (52)	0.152	13 (52)	12 (48)	0.083
Histopathological type
IDC	25 (56.8)	19 (43.2)	1.000^FE	17 (38.6)	27 (61.4)	0.672^FE
ILC	4 (66.7)	2 (33.3)	1.000^FE	3 (50)	3 (50)	0.672^FE
Pathological grade
Early (GI + GII)	21 (58.3)	15 (41.7)	0.939	12 (33.3)	24 (66.7)	0.123
Late (GIII)	8 (57.1)	6 (42.9)	0.939	8 (57.1)	6 (42.9)	0.123
Lymph vascular invasion	27 (62.8)	16 (37.2)	0.115^FE	14 (32.6)	29 (67.4)	0.012*^FE
LN metastasis	19 (67.9)	9 (32.1)	0.111	7 (25)	21 (75)	0.015*
TNM stage
IA	4 (44.4)	5 (55.6)	0.709^MC	6 (66.7)	3 (33.3)	0.061^MC
IIA+IIB	19 (59.4)	13 (40.6)		13 (40.6)	19 (59.4)
III	6 (66.7)	3 (33.3)		1 (11.1)	8 (88.9)
ER positive	21 (58.3)	15 (41.7)	0.939	10 (27.8)	26 (72.2)	0.005*
PR positive	18 (56.3)	14 (43.8)	0.738	9 (28.1)	23 (71.9)	0.022*
HER2/neu positive	22 (56.4)	17 (43.6)	0.741^FE	18 (46.2)	21 (53.8)	0.163^FE
Molecular type
Luminal A	7 (63.6)	4 (36.4)	0.741^FE	2 (18.2)	9 (81.8)	0.163^FE
Luminal B	14 (56)	11 (44)	0.774	8 (32)	17 (68)	0.248
HER2 enriched	8 (57.1)	6 (42.9)	0.939	10 (71.4)	4 (28.6)	0.005*

IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, LN lymph node, TNM tumor-node-metastasis classification system, ER estrogen receptors, PR progesterone receptors, HER2/neu human epidermal growth factor receptor 2
P value, compares the studied groups using χ² Chi-square test, MC Monte Carlo, FE Fisher’s exact tests; *, statistical significance at P ≤ 0.05

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