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Egyptian Journal of Medical Human Genetics

Table 4 Association of the genetic variance of NAMPT rs4730153 with MetS stratified for age

From: A genetic variant of the NAMPT gene rs4730153 as a risk factor for the metabolic syndrome in younger age: a single-centre pilot study in Yogyakarta, Indonesia

rs4730153

Age ≤ 45 years old

Age > 45 years old

MetS

n = 40

Control

n = 40

p-value

OR (95% CI)

MetS

n = 44

Control

n = 44

p-value

OR (95% CI)

Genotype

 Additive model

  AA

3

7

ref

 

9

5

ref

 

  GA

9

11

0.350b

1.91 (0.38–9.6)

13

14

0.326a

0.516 (0.14–1.9)

  GG

28

22

0.124b

2.97 (0.69–12.8)

22

25

0.251a

0.49 (0.14–1.68)

 Recessive/dominant model

  AA

3

7

ref

 

9

5

ref

 

  GG+GA

37

33

0.176a

2.61 (0.63–10.95)

35

39

0.244a

0.500 (0.15–1.63)

  AA+GA

12

18

ref

 

22

29

ref

 

  GG

28

22

0.166a

1.91 (0.76–4.79)

22

25

0.521a

0.76 (0.33–1.76)

 A allele

15

25

ref

1.97

31

24

ref

0.69

 G allele

65

55

0.068a

(0.94–4.1)

57

64

0.255a

(0.36–1.31)

  1. aChi-square test; bFischer exact test. MetS metabolic syndrome, OR odds ratio with 95% CI, ref reference genotype
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