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Fig. 4 | Egyptian Journal of Medical Human Genetics

Fig. 4

From: Chanarin–Dorfman syndrome: clinical/genetic features and natural history in six Pakistani patients

Fig. 4

a Phylogenetic tree shows the conservation of Abhd5 protein in other orthologs (across different species).The evolutionary history was inferred using the Neighbor–Joining method [1]. The optimal tree with the sum of branch length = 1.01547038 is shown. The evolutionary distances were computed using the Poisson correction method. b Multiple sequence alignment of Abhd5 protein showing high conservation of amino acids across the mutated region of c.730–731insA (p.Thr244Asnfs*10) variation among different species. Mutation position marked in black box

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