MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers

Zangoue, Malihe; Zangouei, Amir Sadra; Mojarrad, Majid; Moghbeli, Meysam

doi:10.1186/s43042-021-00190-9

Egyptian Journal of Medical Human Genetics

Table 1 All of the miRNAs which have been reported to regulate the protein kinases in bladder and prostate cancers

From: MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers

Gene	Target	Cancer	Sample	Results	Country	Year	Study
Class I receptors of tyrosine kinases
miR-133a/b	EGFR	Bladder	2 cell lines	The miR133a and miR-133b reduced tumor growth, cell proliferation, and migration	China	2012	Zhou [39]
miR-135a	EGFR	Prostate	141 patients 2 cell lines	MiR-135a suppressed cell proliferation and migration	China	2016	Xu [40]
miR-875-5p	EGFR	Prostate	2 cell lines	The miR-875-5p promoted radiosensitivity	Italy	2017	Bezawy [44]
miR-200a	EGFR	Bladder	3 cell lines	MiR-200a downregulation promoted of EGFR translation and enhancement of anchorage-independent tumor growth	USA	2017	Huang [64]
miR-133a/b	EGFR	Prostate	2 cell lines	MiR-133 functions as a potent tumor suppressor agent, especially in androgen-independent PCa	China	2012	Tao [65]
miR-4319	Her-2	Prostate	40 patients 2 cell lines	Suppressed growth and chemoresistance	USA	2018	Lin [69]
miR-331-3p	Her-2	Prostate	1 cell line	MiR-331-3p was associated with PCa progression	Australia	2011	Epis [73]
miR-148a-3p	ERBB3	Bladder	59 patients 5 cell lines	Suppressed EMT	China	2016	Wang [75]
Class V, VII, and VIII receptors of tyrosine kinases
miR-99a	FGFR3	Prostate	2 cell lines	Inhibited PCa cell growth, invasion, and migration	China	2014	Wu [79]
miR-100	FGFR3	Bladder	4 cell lines	Hypoxia increased viability of tumor cells under stressful conditions through miR-100 suppression	UK	2013	Blick [84]
miR-1-3p	TrkB	Bladder	38 patients 5 cell lines	Inhibited the progression and invasion of BCa	China	2018	Gao [86]
miR-34C	MET	Prostate	47 patients 6 cell lines	There was an inverse correlation between MET and miR-34c expression levels	Sweden	2013	Hagman [95]
miR-323a	c-Met	Bladder	20 patients 5 cell lines	Induced apoptosis	China	2019	Qiu [99]
miR-409-3p	c-Met	Bladder	10 patients 5 cell lines	Inhibited BCa migration and invasion	China	2013	Xu [100]
miR-23b/27b	EGFR, c-MET	Bladder	58 patients 2 cell lines	Suppressed proliferation and migration of BCa cells	Japan	2014	Chiyomaru [101]
miR-101	c-Met	Bladder	10 patients 2 cell lines	Repressed BCa invasion	China	2013	Hu [106]
miR-323a-3p	MET	Bladder	9 patients 4 cell lines	Inhibited invasion and migration of BCa cell lines	China	2017	Li [107]
miR-1	c-Met	Prostate	3 cell lines	Repressed the proliferation	China	2019	Gao [108]
Class II and X receptors of tyrosine kinases
miR‐139	IGF1R, AXL	Prostate	585 patients 3 cell lines	Inhibited PCa cell migration, proliferation, and cell cycle	Canada	2019	Nam [113]
miR-145	IGFIR	Bladder	3 cell lines	Tumor suppressor	China	2014	Zhu [114]
Let-7a1	IGF1R	Prostate	1 cell line	Suppressed prostate tumor cell proliferation, and triggers cell cycle arrest and apoptosis	China	2013	Wang [118]
Non-receptor tyrosine kinases
miR-4723	ABL	Prostate	57 patients 2 cell lines	Inhibited tumor cell proliferation and invasion and induced apoptosis	USA	2013	Arora [121]
miR‐20a	ABL2	Prostate	30 patients 5 cell lines	Inhibited migration and invasion of PCa cells	China	2014	Qiang [126]
miR-3607	SRC	Prostate	100 patients 5 cell lines	Suppressed the tumorigenicity	USA	2014	Saini [130]
miR-1	SRC	Prostate	139 patients 2 cell lines	There was an inverse association between miR-1 and SRC expression levels	Taiwan/USA	2015	Liu [137]
miR-124	SRC	Prostate	4 cell lines	Inhibited PCa cell proliferation, increased sensitivity to enzalutamide, and triggered apoptosis	USA	2015	Shi [140]
miR-1178-3p	SRC	Bladder	82 patients 3 cell lines	The circFNDC3B upregulation suppressed BCa growth and metastasis via miR-1178-3p sponging	China	2018	Liu [143]
miR-199a	YES1	Prostate	74 patients 1 cell line	Increased chemosensitivity and apoptotic cell death	China	2017	Chen [146]
miR-631	ZAP70	Prostate	43 patients 6 cell lines	Suppressed invasion and migration of prostate tumor cells	China	2016	Fu [150]
miR-214	PTK6	Prostate	5 cell lines	Reduced cell proliferation and viability in PCa	USA	2019	Cagle [154]
Serine threonine kinases
miR-27a	MAP2K4	Prostate	17 patients 5 cell lines	Tumor suppressor	China	2016	Wan [157]
miR-136	MAP2K4	Prostate	27 patients 5 cell lines	Suppressed proliferation and invasion of PCa cells	China	2018	Zhu [158]
miR-1826	MEK1	Bladder	19 patients 4 cell lines	Inhibited cancer cell viability and invasion, and induced apoptosis	USA	2012	Hirata [162]
miR-30e	MAPK	Prostate	57 patients 2 cell lines	Inhibited PCa cell invasion and migration	China	2018	Zheng [170]

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