Table 2 Validation of significant DEGs using DisGeNET and literature evidence for their related diseases. log₂|FC| values are derived from ExAtlas meta-analysis web server

CTSL

1.47¹

Disease: Meningioma

Disease Class: Neoplasms; Nervous System Diseases [79]

Skin Proteome and Degradome [80]

Disease: Liver carcinoma

Disease Class: Digestive System Diseases; Neoplasms [81]

Keratinocytes and perturbation of hair Follicle cycling [82]

Disease: Hereditary Diffuse Gastric Cancer

Disease Class: Digestive System Diseases; Neoplasms [83]

Mouse skin carcinogenesis [84]

RFPL4AL1

*Paralog of FPL4A gene

1.56¹

Disease: Malignant neoplasms

Class: Neoplasms

Disease: Colorectal carcinoma

Class: Digestive System Diseases; Neoplasms

Disease: Primary malignant neoplasm

Class: Neoplasms [85]

Malignant melanoma [86]

COVID-19 disease [87]

Hepatocellular carcinoma [88]

TNFRSF11B

1.62¹

Disease: Hyperphosphatasemia with bone disease

Disease Class: Musculoskeletal Diseases [89]

Skin inflammation [90]

Disease: Osteoporosis

Disease Class: Nutritional and Metabolic Diseases; Musculoskeletal Diseases [91]

Skeletal dysplasias [92]

Disease: Rheumatoid Arthritis

Disease Class: Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases [93]

SPACA5

1.64¹

No matches found

Bladder cancer [94]

TMEM158

1.88¹

Disease: Neoplasms [95]

Pediatric localized scleroderma skin [96]

Disease: Carcinogenesis

Disease Class: Pathological Conditions, Signs, and Symptoms; Neoplasms [97]

Anaplastic large cell lymphoma

[97]

Disease: Ovarian neoplasm

Disease Class: Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases [98]

Skin [99]

DNLZ

1.93¹

Disease: Neoplasms [100]

Immune evasion[101]

Disease: Liver carcinoma

Disease Class: Digestive System Diseases; Neoplasms [102]

Fibrogenic responses [103]

Disease: Tumor cell invasion [104]

Psoriasis [105]

MIR614

2.00¹

Disease: ovarian neoplasm; malignant neoplasm of ovary; carcinoma, ovarian epithelial

Disease Class: Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases [106]

Psoriasis [107]

Suppression of stromal interferon signaling [108]

MIR1282

2.00¹

No matches found

Breast cancers [109]

Hepatocellular carcinoma [110]

Associated with immune organs and immunocytes [111]

MIR4469

2.58¹

Disease: Malignant neoplasm of breast; breast carcinoma

Disease Class: Neoplasms; Skin and Connective Tissue Diseases [112]

Atherosclerosis [113]

Laryngeal carcinoma cells [114]

LOC100287497

(SEPTIN7P13)

0.50²

No matches found

Hepatocellular carcinoma [114]

Urinary bladder cancer [115]

OR9I1

0.59²

No matches found

Human keratinocytes [116]

CNNM3-DT

0.60²

Disease: Rheumatoid arthritis

Disease Class: Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases [117]

Lipid metabolism [118]

ENDOU

0.61²

Disease: Mental depression

Disease Class: Behavior Mechanisms [119]

Skin diseases [120]

Disease: Depressive disorder

Disease Class: Mental Disorders [121]

Disease: Depressed mood

Disease Class: Behavior and Behavior Mechanisms [122]