| |
MCL1
|
BCL2
|
BCL-XL
|
|---|
|
Negative (n = 24)
|
Positive (n = 46)
|
P
|
Negative (n = 20)
|
Positive (n = 50)
|
P
|
Negative (n = 24)
|
Positive (n = 46)
|
P
|
|---|
|
FAB
|
|
APL (n = 11)*
|
5
|
6
|
NS
|
5
|
6
|
NS
|
5
|
6
|
NS
|
|
Non-APL (n = 59)
|
19
|
40
|
15
|
44
|
19
|
40
|
|
Performance status
|
|
0/1 (n = 33)
|
14
|
19
|
NS
|
8
|
25
|
NS
|
16
|
17
|
NS
|
|
2/3 (n = 37)
|
10
|
27
|
12
|
25
|
8
|
29
|
|
Early death†
|
|
No (n = 48)
|
17
|
31
|
NS
|
10
|
38
|
0.02
|
17
|
31
|
NS
|
|
Yes (n = 20)
|
7
|
13
|
10
|
10
|
7
|
13
|
|
Apoptosis medians (ranges)
|
|
Annxine V
|
3.8 (0.4–9.1)
|
4.9 (0.3–13.6)
|
NS
|
2.7 (0.4–8.4)
|
4.8 (0.3–13.6)
|
0.03
|
3.8 (0.4–9.5)
|
4.5 (0.3–13.6)
|
NS
|
|
Anx&PI‡
|
3.4 (0.6–13.9)
|
5.5 (0.6–17.1)
|
NS
|
2.5 (0.6–7.8)
|
5.5 (0.6–17.1)
|
0.003
|
3.5 (0.6–12.3)
|
5.5 (0.6–17.1)
|
NS
|
|
Total apoptosis
|
8.3 (1.7–18.6)
|
10.4 (2.9–19.3)
|
NS
|
4.6 (1.7–14.3)
|
11.1 (2.9–19.3)
|
0.001
|
8.3 (1.7–17.7)
|
10.4 (2.9–19.3)
|
NS
|
- *Acute Promyelocytic Leukemia
- †Two patient left hospital at the induction
phase
- ‡Annexine V and Propidium Iodide
- Mann–Whitney’s U test, Pearson Chi-square or Fisher exact test was carried out as specified in the method section
- Significant P values are written in bold; NS, not significant
