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Table 2 Assessment of variant allele frequency and MSI status

From: Targeted next generation sequencing provides insight for the genetic alterations in liquid biopsy of Egyptian brain tumor patients

Variant No. of patients P1 P2 P3 P4 P5 P6 P7
GBM grade IV GBM grade IV GBM grade IV GBM grade IV Astrocytoma grade II GBM grade IV GBM grade IV
FLT3-intronic mutation 5   0.47   0.99 1 0.49 0.51
SMARCB1-intronic mutation 2 0.49      1  
FGFR3 p.Thr653 = -coding silent mutation 7 0.99 0.99 1 0.99 1 0.99 0.99
HRAS p.His27 = -coding silent mutation 2 0.48   0.51     
RET p.Leu769 = -coding silent mutation 7 0.47 1 1 0.51 1 1 0.50
RET p.Ser904 = -coding silent mutation 4 0.53 0.50    0.49   0.49
PDGFRA p.Val824 = -coding silent mutation 3 0.50    0.51   0.49  
PDGFRA p.Pro567 = -coding silent mutation 7 1 0.99 1 0.99 1 1 0.99
MET p.Ser178 = -coding silent mutation 2   0.50    0.48   
MET p.Ile377 = -coding silent mutation 1   0.47      
CDKN2A p.Arg58 = -coding silent mutation 1      0.51   
EGFR p.Gln787 = -coding silent mutation 6 0.99 0.48   0.99 0.99 1 0.51
APC p.Thr1493 = -coding silent mutation 4 0.99    0.48 0.99   0.47
IDH1 p.Gly105 = -coding silent mutation 1   0.49      
KIT p.Met541Leu—missense mutation 2    0.48   0.47   
TP53 p.Pro72Arg—missense mutation 6   0.46 0.50 0.52 1 0.51 0.99
KDR p.Gln472His—missense mutation 4    0.51   0.16 0.47 0.49
JAK3 p.Val718Leu—missense mutation 1        0.51
MSI status 7 MSI-L MSI-HI MSI-L MSI-HI MSI-L MSI-L MSI-HI
  1. GMB glioblastoma, MSI-L microsatellite instability-low, MSI-HI microsatellite instability-high