Variant | No. of patients | P1 | P2 | P3 | P4 | P5 | P6 | P7 |
---|---|---|---|---|---|---|---|---|
GBM grade IV | GBM grade IV | GBM grade IV | GBM grade IV | Astrocytoma grade II | GBM grade IV | GBM grade IV | ||
FLT3-intronic mutation | 5 | 0.47 | 0.99 | 1 | 0.49 | 0.51 | ||
SMARCB1-intronic mutation | 2 | 0.49 | 1 | |||||
FGFR3 p.Thr653 = -coding silent mutation | 7 | 0.99 | 0.99 | 1 | 0.99 | 1 | 0.99 | 0.99 |
HRAS p.His27 = -coding silent mutation | 2 | 0.48 | 0.51 | |||||
RET p.Leu769 = -coding silent mutation | 7 | 0.47 | 1 | 1 | 0.51 | 1 | 1 | 0.50 |
RET p.Ser904 = -coding silent mutation | 4 | 0.53 | 0.50 | 0.49 | 0.49 | |||
PDGFRA p.Val824 = -coding silent mutation | 3 | 0.50 | 0.51 | 0.49 | ||||
PDGFRA p.Pro567 = -coding silent mutation | 7 | 1 | 0.99 | 1 | 0.99 | 1 | 1 | 0.99 |
MET p.Ser178 = -coding silent mutation | 2 | 0.50 | 0.48 | |||||
MET p.Ile377 = -coding silent mutation | 1 | 0.47 | ||||||
CDKN2A p.Arg58 = -coding silent mutation | 1 | 0.51 | ||||||
EGFR p.Gln787 = -coding silent mutation | 6 | 0.99 | 0.48 | 0.99 | 0.99 | 1 | 0.51 | |
APC p.Thr1493 = -coding silent mutation | 4 | 0.99 | 0.48 | 0.99 | 0.47 | |||
IDH1 p.Gly105 = -coding silent mutation | 1 | 0.49 | ||||||
KIT p.Met541Leu—missense mutation | 2 | 0.48 | 0.47 | |||||
TP53 p.Pro72Arg—missense mutation | 6 | 0.46 | 0.50 | 0.52 | 1 | 0.51 | 0.99 | |
KDR p.Gln472His—missense mutation | 4 | 0.51 | 0.16 | 0.47 | 0.49 | |||
JAK3 p.Val718Leu—missense mutation | 1 | 0.51 | ||||||
MSI status | 7 | MSI-L | MSI-HI | MSI-L | MSI-HI | MSI-L | MSI-L | MSI-HI |