Table 3 Association of eNOS and TGF-β1 gene polymorphisms in T2DM patients with and without DN
Gene(rsID) | Models | T2DM patients with DN N = 140 | T2DM patients without DN N = 140 | Odds ratio (95% CI) | P value |
|---|---|---|---|---|---|
Co dominant model | |||||
GG | 73 | 80 | 1.00 | – | |
GT | 24 | 32 | 0.69 (0.38–1.26) | 0.23 | |
TT | 45 | 28 | 1.89 (1.09–3.26) | 0.02* | |
eNOS (rs1799983) | Dominant model-GT + TT vs GG | 78 | 65 | 1.45 (0.90–2.32) | 0.12 |
Recessive model-TT vs GG + GT | 87 | 60 | 2.18 (1.35–3.53) | 0.001* | |
Allelic model | |||||
Allele G | 177 | 212 | 1.00 | – | |
Allele T | 103 | 68 | 0.55 (0.39–0.79) | 0.001* | |
Co dominant model | |||||
GG | 85 | 82 | 1.00 | – | |
GC | 29 | 30 | 0.95 (0.53–1.70) | 0.87 | |
CC | 26 | 28 | 0.91 (0.50–1.65) | 0.76 | |
TGF-β1 (rs1800471) | Dominant model-GC + CC vs GG | 57 | 62 | 0.86 (0.53–1.38) | 0.54 |
Recessive model-CC vs GG + GC | 68 | 73 | 0.87 (0.54–1.38) | 0.56 | |
Allelic model | |||||
Allele G | 180 | 176 | 1.00 | – | |
Allele C | 100 | 104 | 1.06 (0.75–1.50) | 0.72 |