Table 5 Association of eNOS and TGF-β1 gene polymorphisms in T2DM patients without DN and Controls
Gene(rsID) | Models | T2DM patients without DN N = 140 | Controls N = 140 | Odds ratio (95% CI) | P value |
|---|---|---|---|---|---|
Co dominant model | |||||
GG | 80 | 82 | 1.00 | – | |
GT | 38 | 42 | 0.86 (0.51–1.46) | 0.59 | |
TT | 22 | 16 | 1.44 (0.72–2.88) | 0.29 | |
eNOS (rs1799983) | Dominant model-GT + TT vs GG | 63 | 59 | 1.12 (0.70–1.80) | 0.62 |
Allelic model | |||||
Allele G | 212 | 225 | 1.00 | – | |
Allele T | 68 | 55 | 0.76 (0.50–1.13) | 0.18 | |
Co dominant model | |||||
GG | 82 | 79 | 1.00 | – | |
GC | 30 | 32 | 0.92 (0.52–1.61) | 0.77 | |
CC | 28 | 29 | 0.95 (0.53–1.71) | 0.88 | |
TGF-β1 (rs1800471) | Dominant model- GC + CC vs GG | 62 | 67 | 0.86 (0.54–1.38) | 0.54 |
Recessive model-CC vs GG + GC | 45 | 57 | 0.68 (0.42–1.12) | 0.13 | |
Allelic model | |||||
Allele G | 176 | 171 | 1.00 | – | |
Allele C | 104 | 109 | 1.07 (0.76–1.51) | 0.66 |