Table 5 Active site amino acids of WNT signalling proteins
Protein | Area (SA) | Volume (SV) | Active site amino acids |
|---|---|---|---|
APC | 5143.368 | 5419.876 | Ser410, Ser202, His123, Asp65, Asp126, His248, Cys82, Asp500, Asn501, Thr365 |
AXIN | 339.096 | 284.884 | Asn102, Ala106, Glu107, |
β-catenin | 6846.710 | 18,020.249 | Asp299, Leu264, Gln302, Arg274, Asn290, |
GSK-3β | 3206.606 | 4409.052 | Val214, Arg108, Lys205, Arg96, Arg209, |
DSH | 3798.556 | 6489.172 | Asn33, Tyr153, Asp71, Asp72, Asn28, His66. Asn67, His78 |