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Table 2 Association between risk stratification and response to treatment with the studied parameters

From: Clonal heterogeneity by fluorescence in situ hybridization in multiple myeloma: enhanced cytogenetic risk stratification

 

Risk stratification

P value

Response to treatment

P value

Standard risk

Intermediate risk

High risk

Non-responders

Responders

No. = 41

No. = 10

No. = 9

No. = 21

No. = 39

Sex

 Females

16 (39.0%)

4 (40.0%)

3 (33.3%)

0.944

10 (47.6%)

13 (33.3%)

0.278

 Males

25 (61.0%)

6 (60.0%)

6 (66.7%)

 

11 (52.4%)

26 (66.7%)

 

HB (gm/dL)

 ≥ 10

20 (48.8%)

0 (0.0%)

0 (0.0%)

0.001

1 (4.8%)

19 (48.7%)

0.001

 < 10

21 (51.2%)

10 (100.0%)

9 (100.0%)

 

20 (95.2%)

20 (51.3%)

 

Creat (mg/dL)

 ≤ 2

29 (70.7%)

4 (40.0%)

4 (44.4%)

0.103

11 (52.4%)

26 (66.7%)

0.278

 > 2

12 (29.3%)

6 (60.0%)

5 (55.6%)

 

10 (47.6%)

13 (33.3%)

 

Ca (mg/dL)

 ≤ 11

32 (78.0%)

4 (40.0%)

1 (11.1%)

0.000

9 (42.9%)

28 (71.8%)

0.028

 > 11

9 (22.0%)

6 (60.0%)

8 (88.9%)

 

12 (57.1%)

11 (28.2%)

 

 Positive

41 (100.0%)

10 (100.0%)

9 (100.0%)

    

IPT

 Lambda

9 (22.0%)

7 (70.0%)

8 (88.9%)

0.000

16 (76.2%)

8 (20.5%)

0.000

 Kappa

32 (78.0%)

3 (30.0%)

1 (11.1%)

 

5 (23.8%)

31 (79.5%)

 

ISS

 I

21 (51.2%)

2 (20.0%)

2 (22.2%)

0.000

3 (14.3%)

22 (56.4%)

0.000

 II

15 (36.6%)

2 (20.0%)

0 (0.0%)

 

2 (9.5%)

15 (38.5%)

 

 III

5 (12.2%)

6 (60.0%)

7 (77.8%)

 

16 (76.2%)

2 (5.1%)

 

RISS

 I

7 (17.1%)

0 (0.0%)

0 (0.0%)

0.000

3 (14.3%)

4 (10.3%)

0.003

 II

34 (82.9%)

3 (30.0%)

2 (22.2%)

 

8 (38.1%)

31 (79.5%)

 

 III

0 (0.0%)

7 (70.0%)

7 (77.8%)

 

10 (47.6%)

4 (10.3%)

 
  1. * values at risk
  2. ISS international staging system, RISS revised international staging system, HB hemoglobin, Creat serum creatinine, Ca serum calcium, IPT immunophenotyping
  3. *Chi-square test
  4. P value > 0.05: non-significant; P value < 0.05 (bold): significant (bold); P value < 0.01: highly significant