In-silico analysis unravels the structural and functional consequences of non-synonymous SNPs in the human IL-10 gene

Egyptian Journal of Medical Human Genetics

Table 2 Functional and structural modifications of IL-10 predicted by MutPred2. Here ‘g-value’ stands for general score of MutPred2

SNPs	Actionable/confident hypothesis	g-value	p value	Probability
F48L	Gain of relative solvent accessibility	0.705	0.01	0.29
	Altered transmembrane protein		0.0082	0.26
	Altered coiled coil		0.03	0.13
L91V	Gain of loop	0.506	0.02	0.27
	Altered transmembrane protein		0.0025	0.23
	Gain of sulfation at Y 90		0.04	0.02
M95T	Altered transmembrane protein	0.732	0.00085	0.27
M95T	Loss of sulfation at Y 90	0.732	0.04	0.01
A98D	Gain of intrinsic disorder	0.612	0.04	0.31
	Gain of loop		0.0086	0.29
	Gain of B-factor		0.02	0.26
	Altered transmembrane protein		0.0051	0.20
R125S	Altered disorder interface	0.543	0.01	0.30
Y155C	Altered metal binding	0.764	0.00046	0.50
	Altered Ordered interface		0.0044	0.36
	Altered Disordered interface		0.0074	0.36
	Altered Transmembrane protein		0.000063	0.32
	Loss of Relative solvent accessibility		0.0059	0.32
	Loss of Acetylation at K152		0.0078	0.27
	Loss of Allosteric site at E160		0.03	0.23
	Gain of Catalytic site at E160		0.04	0.11
I168T	Altered Disordered interface	0.512	0.0026	0.44
	Altered Ordered interface		0.02	0.30
	Gain of Relative solvent accessibility		0.02	0.27
	Altered Transmembrane protein		0.04	0.10
	Altered Coiled coil		0.04	0.10
	Gain of N-linked glycosylation at N166		0.04	0.02