Egyptian Journal of Medical Human Genetics

Table 4 Results of wild-type and mutant-type amino acid properties obtained from Project Hope software

From: In-silico analysis unravels the structural and functional consequences of non-synonymous SNPs in the human IL-10 gene

Amino Acid change	Wild type amino acids			Mutant type amino acid
Amino Acid change	Size	Charge	Hydrophobicity	Size	Charge	Hydrophobicity
R42G	Larger	Positive	Less	More smaller	Neutral	More hydrophobic
R45Q	Larger	Positive	–	More smaller	Neutral	–
F48L	Larger	–	–	More smaller	–	–
E72G	Larger	Negative	Less hydrophobic	More smaller	Neutral	More Hydrophobic
M95T	Larger	–	More hydrophobic	More smaller	–	Less hydrophobic
A98D	Smaller	Neutral	More hydrophobic	More larger	Negative	Less hydrophobic
R125S	Larger	Positive	Less hydrophobic	Smaller	Neutral	More hydrophobic
Y155C	Larger	–	More hydrophobic	Smaller	–	More hydrophobic
I168T	Larger	–	More hydrophobic	Smaller	–	Less Hydrophobic

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