Fig. 4

Liver, rat. A and B Group 2. A Showing hepatocellular carcinoma which characterized by multiple micronodules of will differentiated hepatocytes (thin arrow) separated by undifferentiated hepatocellular carcinoma (thick arrow). B Showing hepatocellular carcinoma which characterized by mitotic figures (thin arrow) and prominent nucleoli (arrowhead) in hepatocytes. C and D Group 3. C Showing hepatocellular carcinoma which characterized by multiple micronodules (thin arrow) which separated by undifferentiated hepatocellular carcinoma (asterisk). Additionally, Cholangiocarcinoma (arrow) and hemorrhages (bended arrow) can be observed. D) Showing hepatocellular carcinoma which characterized by undifferentiated neoplastic cells (thick arrow), mitosis (thin arrow), and pseudoglandular pattern (arrowhead). E and F Group 4. E Showing hepatocellular carcinoma which characterized by multiple micronodules (thick arrow) which separated by a wide areas of undifferentiated hepatocellular carcinoma (asterisk). Additionally, Cholangiocarcinoma (arrowhead) and hemorrhages (thin arrow) can be observed. F Showing hepatocellular carcinoma which characterized by the presence of mitosis (thick arrow), undifferentiated neoplastic cells (arrowhead), and macrophages containing bile pigment (thin arrow). HE stain. A, C and E × 20; B, D and F × 40