Genetic and molecular biology of gastric cancer among Iranian patients: an update

Abbaszadegan, Mohammad Reza; Mojarrad, Majid; Rahimi, Hamid Reza; Moghbeli, Meysam

doi:10.1186/s43042-022-00232-w

Egyptian Journal of Medical Human Genetics

Table 1 All of the involved markers in gastric cancer susceptibility among the Iranian patients

From: Genetic and molecular biology of gastric cancer among Iranian patients: an update

References	Gene	population	Results
Cell cycle, DNA repair, and apoptosis
Abbaszadegan [15]	P16	52 patients 50 controls	Hyper methylation was correlated with malignant tumors
Moghbeli [17]	hMLH1	51 N/T*	Hyper methylation was correlated with advanced stages
Azarhoush [18]	P53	111 patients	Over-expression was correlated with tumor type
Rezaei [20]	SRBC	40 N/T 20 controls	Hyper methylation was correlated with age
Kordafshari [23]	AdipoR1 and AdipoR2	42 patients 52 controls	Over-expression
MicroRNAs and long non coding RNAs
Ranjbar [31]	miR-19, miR-21	120 patients 102 controls	Over-expression
Ranjbar [31]	miR-146, miR-375, Let-7	120 patients 102 controls	Under-expression
Adami [32]	miR-146a	100 tumors 44 normal	Over-expression
Emami [35]	miR-21, miR-222	30 patients 30 controls	Over-expression
Larki [38]	miR-21, miR-25, miR-93, miR-106b	39 tumors 29 normal	Over-expression
Ziasarabi [39]	miR-17, miR-25, miR-133b	120 patients 102 controls	Increased serum levels of miR-17 and miR-25 reduced levels of miR-133b
Zare [40]	miR-155-5p, miR-15a, miR-186	39 tumors 29 normal	Under-expression
Parvaee [41]	miR107, miR-194, miR-210	50 patients 50 controls	Under-expression
Zare [42]	miR-124-3p, miR-218-5p, miR-484	40 tumors 31 normal	Under-expression
Ebrahimi Ghahnavieh [44]	miR-584	26 patients 11 controls	Over-expression was correlated with h. pylori infection, stage, and lymph node metastasis
Baratieh [54]	PlncRNA-1	35 N/T	Over-expression was correlated with sex and poor prognosis
Salavaty [55]	RAB6C-AS1	30 N/T	Correlation with differentiation
Kangarlouei [59]	ANRIL, ANRASSF1	39 N/T	Over-expression
Behzadi [60]	BC032913	80 N/T	Under-expression
Signaling pathways and transcriptional regulation
Kosari-Monfared [64]	CTNNBIP1	58 N/T	Under-expression was correlated with sex and grade
jafari [69]	NOTCH1 and GATA6	24 N/T	NOTCH1 under-expression was correlated with distant metastasis
Ghadami [72]	CYLD	53 N/T	Under-expression was correlated with sex, grade, and age
Pilehchian Langroudi [76]	FAT4	30 N/T	FAT4 expression was inversely correlated with grade
Nasrollahzadeh-Khakiani [80]	CEBPA, UCA1	40 N/T	Over-expression
Moghbeli [81]	ERBB1, ERBB3	50 N/T	EGFR and ERBB3 co-overexpression was correlated with age and tumor size
Ayatollahi [83]	KRAS	120 patients	Mutation
Dokhaee [86]	GKN1	27 patients	Under-expression
Behroozi [88]	ADAR	42 N/T	Over-expression was significantly correlated with stage, poor prognosis, and tumor size
Abbaszadegan [90]	MAEL	80 N/T	MAEL had higher levels of expression in primary-stage tumors
Soleymani Fard [92]	AR	60 N/T 50 controls	Over-expression was positively correlated with increased lymph node involvement, tumor size, higher distant metastasis, and advanced stages
Inflammation
Mohammadian Amiri [97]	NOD1, NOD2	39 patients 52 controls	Over-expression
Naghavi-Alhosseini [101]	TIM-3	43 patients 42 controls	Over-expression
Attar [105]	IL-6	100 patients 361 controls	Polymorphism was correlated with GC
Taghizadeh [109]	VEGF-C	38 patients 52 controls	Over-expression
Kashfi [113]	IL-16	256 patients 300 controls	Polymorphism was correlated with GC
Rafiei [116]	IL-17	161 patients 171 controls	Polymorphism was correlated with stage
Rafiei [120]	iNOS	159 patients 170 controls	Polymorphism was correlated with GC
Abbasian [122]	IL-1	35 patients 97 controls	Polymorphism was correlated with GC
Amini [123]	CD40	25 N/T	Hyper methylation
Stemness and self-renewal
Samadani [127]	CDX2	–	Hypo methylation
Dabiri [129]	OLFM4	25 patients 10 controls	Over-expression
Nikpour [131]	ZFX	30 N/T	ZFX expression was correlated with grade
Rahmati [132]	ZFX	30 N/T	Over-expression was correlated with grade and size
Nikkhoo [134]	CXCR4	43 patients	CXCR4 expression was correlated with survival
Haghverdi [136]	PAX5	35 patients 35 controls	Under-expression
Cell adhesion and structural factors
Menbari [139]	CDH1	50 patients 54 controls	Polymorphism was correlated with survival
Eyvazi [141]	CDH11 and HS3ST2	40 patients 40 controls	Hyper methylation
Bitaraf [144]	CD44	150 patients 150 controls	Polymorphism was correlated with survival
Mokhtarian [145]	CD44	86 patients 96 controls	Polymorphism was correlated with GC
Alikhani [147]	MUC1	99 patients 96 controls	Polymorphism was correlated with GC
Esfandi [150]	AFAP1	30 N/T	Under-expression
Daryabari [155]	SSH1	40 N/T	Over-expression
Esfandi [159]	BACE1	30 N/T	Under-expression
Tavabe Ghavami [162]	Gelsolin and Scinderin	41 patients	Gelsolin downregulation and Scinderin upregulation were associated with lymph node involvement

*Tumor tissues and normal margins

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