Association of FTO gene variant rs9939609 with hyperandrogenemia and fasting glucose levels in South Indian women with polycystic ovarian syndrome

Egyptian Journal of Medical Human Genetics

Table 1 Comparison of metabolic and endocrine characteristic between PCOS and controls

Characteristics	PCOS n = 100	Control n = 70	P value	P value adj
Age (year)	25.42 ± 2.91	23.08 ± 3.25	< 0.001	Nil
BMI (kg/m²)	26.17 ± 5.42	23.61 ± 4.88	0.002	Nil
WC (cm)	92.11 ± 13.13	84.58 ± 10.94	< 0.001	0.037
WHR	0.91 ± 0.08	0.90 ± 0.05	0.168	0.871
Ferriman-Gallwey score	11.70 ± 5.22	Nil	Nil	Nil
SBP (mmHg)	126.31 ± 10.48	117 ± 11.83	< 0.001	< 0.001
DBP (mmHg)	81.72 ± 5.39	75.08 ± 5.51	< 0.001	< 0.001
Cholesterol (mg/dL)	218.49 ± 50.77	186.98 ± 72.44	0.002	0.010
Triglycerides (mg/dL)	148.30 ± 66.69	135.80 ± 35.97	0.116	0.612
HDL (mg/dL)	39.70 ± 12.91	43.43 ± 9.78	0.043	0.040
LDL (mg/dL)	149.13 ± 46.17	121.09 ± 68.88	0.004	0.005
Fasting glucose (mg/dL)	95.93 ± 13.16	91.28 ± 13.82	0.027	0.16
Insulin (mU/L)	13.84 ± 4.76	10.96 ± 3.38	< 0.001	< 0.001
HOMA-IR	3.32 ± 1.32	2.53 ± 0.96	< 0.001	< 0.001
QUICKI	0.049 ± 0.01	0.49 ± 0.01	0.002	0.005
LH (mlU/ml)	11.78 ± 5.81	8.62 ± 5.42	< 0.001	0.001
FSH (mlU/ml)	4.73 ± 1.80	5.41 ± 2.76	0.062	0.065
LH/FSH	2.64 ± 1.55	1.46 ± 0.43	< 0.001	< 0.001
Testosterone (nmol/L)	2.07 ± 0.47	1.63 ± 0.48	0.001	0.002

BMI, Body mass index; WC, waist circumference; WHR, waist-to-hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HOMA-IR, homeostasis model for insulin resistance; QUICKI, quantitative insulin sensitivity check index; LH, luteinizing hormone; FSH, follicle-stimulating hormone
Values are expressed as mean ± standard deviation (Student's t test); Bold values indicate significant P-values (P ≤ 0.05). P value adj shows adjusted P value by age and BMI through ANCOVA (analysis of covariance)