Association of FTO gene variant rs9939609 with hyperandrogenemia and fasting glucose levels in South Indian women with polycystic ovarian syndrome

Egyptian Journal of Medical Human Genetics

Table 3 Metabolic and endocrine characteristics of the PCOS group according to different genotypes for SNP rs9939609

Variable	T/T n = 28	A/T n = 57	A/A n = 15	P value	P value adj
Age (year)	24.96 ± 5.83	24.98 ± 4.35	28 ± 4.65	0.08	Nil
BMI (kg/m²)	22.52 ± 3.95^a	27.58 ± 5.46^b	27.51 ± 4.64^b	< 0.001	Nil
WC (cm)	91.30 ± 11.35	91.60 ± 13.87	95.60 ± 13.57	0.54	0.09
WHR	0.91 ± 0.06	0.91 ± 0.09	0.93 ± 0.06	0.63	0.04
Ferriman-Gallwey score	9.86 ± 1.59	10.67 ± 3.25	12.67 ± 6.32	0.89	0.16
SBP (mmHg)	125.56 ± 9.17	125.72 ± 10.72	129.97 ± 11.73	0.34	0.96
DBP (mmHg)	82.48 ± 5.25	80.86 ± 5.38	83.64 ± 5.31	0.14	0.57
Cholesterol (mg/dL)	219.21 ± 62.61	216.28 ± 41.70	225.59 ± 60.79	0.81	0.60
Triglycerides (mg/dL)	152.01 ± 75.47	144.75 ± 63.37	155.06 ± 65.65	0.81	0.241
HDL (mg/dL)	41.12 ± 12.91	39.68 ± 12.81	37.13 ± 13.74	0.63	0.26
LDL (mg/dL)	147.74 ± 59.78	147.65 ± 37.84	157.44 ± 49.21	0.75	0.47
Fasting glucose(mg/dL)	88.46 ± 9.61^a	98.27 ± 13.21^b	100.80 ± 13.72^b	0.001	0.006
Insulin (mU/L)	13.91 ± 5.13	13.60 ± 4.85	14.64 ± 3.85	0.75	0.49
HOMA-IR	3.19 ± 1.23	3.34 ± 1.44	3.51 ± 1	0.74	0.33
QUICKI	0.49 ± 0.01	0.49 ± 0.01	0.48 ± 0.01	0.26	0.08
LH (mlU/ml)	13.32 ± 5.71	10.98 ± 6.13	11.97 ± 4.21	0.21	0.32
FSH (mlU/ml)	4.94 ± 2.22	4.60 ± 1.73	4.85 ± 1.14	0.69	0.35
LH/FSH	3.10 ± 1.86	2.60 ± 1.52	2.68 ± 0.86	0.36	0.29
Testosterone (nmol/L)	1.85 ± 0.34^a	2.11 ± 0.45^b	2.32 ± 0.62^b	0.004	< 0.001

BMI, Body mass index; WC, waist circumference; WHR, waist-to-hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HOMA-IR, homeostasis model for insulin resistance; QUICKI, quantitative insulin sensitivity check index; LH, luteinizing hormone; FSH, follicle-stimulating hormone
Values are expressed as mean ± standard deviation (one-way ANOVA); Bold value indicate significant p-value (p ≤ 0.05). Different letters “a, b” express statistical differences between groups in post hoc analysis. P value adj shows adjusted P value by BMI through ANCOVA (analysis of covariance)