Impact of IL-28B gene polymorphism on chronic hepatitis-C patients progression with diabetes and non-diabetes

Egyptian Journal of Medical Human Genetics

Table 4 Relation between IL28 B genotype and ALT / and viral load by PCR for the all studied patients

Parameter	CC (n = 40)	CT (n = 82)	TT (n = 38)	K	p
ALT(U/L) Mean ± SD Median Range	37.35 ± 26.02 30 10–143	54.49 ± 27.21 50.5 14–161	71.58 ± 33.83 63 15–175	34.39	< 0.001***
PCR (IU/mL) Mean ± SD Median Range	153,050 ± 399,946 31,000 1600–1,800,000	1,081,300 ± 2,754,340 90,000 1200–16,200,000	578,060 ± 1,454,550 380,000 3200–7,500,000	11.45	0.003*

ALT: alanine aminotransferase PCR: polymerase chain reaction SD: standard deviation K = Kruskal–Wallis test ***: highly significant
Least significant difference (LSD) of ALT between genotypes: (CC versus CT p = 0.002 CC versus TT p = < 0.001. CT versus TT p = 0.004). LSD of PCR between genotypes: (CC versus CT p = 0.034. CC versus TT p = 0.009. CT versus TT p = 0.01)