The first combined meta‐analytic approach for elucidating the relationship of circulating resistin levels and RETN gene polymorphisms with colorectal and breast cancer

Egyptian Journal of Medical Human Genetics

Table 3 Characteristics of selected studies evaluating RETN gene polymorphisms included in the meta-analysis

Study ID	Year	Country	Cancer type	Genotyping method	Cases	Controls	Cases			Controls			HWE p-value	NOS score
Study ID	Year	Country	Cancer type	Genotyping method	Cases	Controls	GG	GC	CC	GG	GC	CC	HWE p-value	NOS score
RETN rs1862513
Al-Harithy et al	2010	KSA	CRC	PCR–RFLP	60	60	11	33	16	16	20	24	0.013	7
Alharithy et al	2014	KSA	CRC	PCR–RFLP	60	60	12	33	15	16	20	24	0.013	8
Duzkoylu et al	2015	Turkey	CRC	PCR–RFLP	123	79	9	61	53	12	36	31	0.772	7
Mahmoudi et al	2014	Iran	CRC	PCR–RFLP	197	217	76	83	38	76	85	56	0.002	8
Pechlivanis et al	2009	Czech Republic	CRC	PCR–RFLP	642	714	63	262	317	56	265	393	0.230	6
Wågsater et al	2008	Sweden	CRC	TaqMan	248	256	26	95	127	16	103	137	0.563	7
Kohan et al	2017	Iran	BC	PCR–RFLP	150	150	37	63	50	24	63	63	0.225	7
Munoz-Palomeque et al	2018	Mexico	BC	PCR–RFLP	100	308	5	42	53	7	102	199	0.144	8
Wang et al	2020	China	BC	TaqMan	515	541	96	205	214	76	241	224	0.390	8
Total			2095	2385	335	877	883	299	935	1151

Study ID	Year	Country	Cancer type	Genotyping method	Cases	Controls	Cases			Controls			HWE p-value	NOS score
Study ID	Year	Country	Cancer type	Genotyping method	Cases	Controls	AA	GA	GG	AA	GA	GG	HWE p-value	NOS score
RETN rs3745367
Alharithy et al	2014	KSA	CRC	PCR–RFLP	60	60	6	51	3	6	39	15	0.011	7
Mahmoudi et al	2016	Iran	CRC	PCR–RFLP	172	190	35	72	65	26	86	78	0.768	8
Wang et al	2020	China	BC	TaqMan	515	541	72	259	184	77	252	212	0.879	7
Total					747	791	113	382	252	109	377	305

BC, breast cancer; CRC, colorectal cancer; HWE, Hardy–Weinberg equilibrium; NOS, Newcastle–Ottawa Scale