The first combined meta‐analytic approach for elucidating the relationship of circulating resistin levels and RETN gene polymorphisms with colorectal and breast cancer

Aziz, Md. Abdul; Akter, Tahmina; Sarwar, Md. Shahid; Islam, Mohammad Safiqul

doi:10.1186/s43042-022-00240-w

Egyptian Journal of Medical Human Genetics

Table 4 Meta-analysis and subgroup analysis of selected studies evaluating the association of RETN gene polymorphisms with colorectal and breast cancer

From: The first combined meta‐analytic approach for elucidating the relationship of circulating resistin levels and RETN gene polymorphisms with colorectal and breast cancer

Genetic model	Test of association			Test of heterogeneity			Publication bias (p-value)
Genetic model	OR	95% CI	p-value	Model	p-value	I² (%)	Egger’s test	Begg-Mazumdar’s test
RETN rs1862513 (CRC)
Codominant 1 (GC vs. CC)	1.24	1.05–1.47	0.010	Fixed	0.165	36.28	0.226	0.091
Codominant 2 (GG vs. CC)	1.31	1.018–1.69	0.036	Fixed	0.292	18.74	0.236	0.348
Codominant 3 (GG vs. GC)	0.85	0.56–1.29	0.444	Random	0.038	57.58	0.125	0.091
Dominant model (GG + GC vs. CC)	1.25	1.07–1.46	0.005	Fixed	0.418	0	0.526	0.188
Recessive model (GG vs. GC + CC)	1.01	0.72–1.43	0.934	Random	0.095	46.74	0.120	0.039
Over dominant (GC vs. GG + CC)	1.25	0.98–1.60	0.070	Random	0.097	46.37	0.168	0.060
Allele contrast (G vs. C)	1.16	1.03–1.30	0.012	Fixed	0.541	0	0.297	0.091
RETN rs1862513 (BC)
Codominant 1 (GC vs. CC)	1.05	0.86–1.30	0.622	Fixed	0.101	56.43	0.244	0.602
Codominant 2 (GG vs. CC)	1.51	1.12–2.03	0.007	Fixed	0.360	2.23	0.166	0.117
Codominant 3 (GG vs. GC)	1.51	1.12–2.04	0.007	Fixed	0.969	0	0.074	0.117
Dominant model (GG + GC vs. CC)	1.16	0.95–1.41	0.135	Fixed	0.109	54.89	0.124	0.602
Recessive model (GG vs. GC + CC)	1.51	1.15–1.99	0.004	Fixed	0.653	0	0.125	0.117
Over dominant (GC vs. GG + CC)	1.02	0.73–1.43	0.912	Random	0.095	57.48	0.346	0.117
Allele contrast (G vs. C)	1.21	1.05–1.40	0.008	Fixed	0.172	43.23	0.033	0.117
RETN rs3745367 (CRC + BC)
Codominant 1 (AG vs. GG)	1.41	0.80–2.48	0.239	Random	0.029	71.64	0.436	0.602
Codominant 2 (AA vs. GG)	1.27	0.93–1.74	0.138	Fixed	0.142	48.71	0.117	0.117
Codominant 3 (AA vs. AG)	1.04	0.77–1.40	0.794	Fixed	0.245	28.99	0.890	0.602
Dominant model (AA + AG vs. GG)	1.42	0.85–2.36	0.182	Random	0.041	68.78	0.287	0.117
Recessive model (AA vs. AG + GG)	1.12	0.84–1.49	0.443	Fixed	0.324	11.32	0.786	0.602
Over dominant (AG vs. AA + GG)	1.24	0.78–1.98	0.359	Random	0.041	68.66	0.627	0.602
Allele contrast (A vs. G)	1.14	0.98–1.31	0.083	Fixed	0.397	0	0.042	0.117

Bold values indicate statistically significant (p < 0.05)
BC, breast cancer; CRC, colorectal cancer; OR, odds ratio; 95% CI, 95% confidence interval

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