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Table 4 Relations of rs3746444 A > G genotypic frequencies to clinical data

From: Pre-microRNAs single nucleotide variants (rs3746444 A > G and rs2910164 C > G) increase the risk of ischemic stroke in the Egyptian population: a case–control study

Parameters rs3746444 A > G rs3746444 A > G
GG
N (%)
AG
N (%)
AA
N (%)
p Value* GG + AG
N (%)
AA
N (%)
p Value*
Age (years)
≤ 40 Years 4 (8.3) 3 (21.4) 4 (10.5) 0.382 7 (11.3) 4 (10.5) 1
> 40 Years 44 (91.7) 11 (78.6) 34 (89.5) 55 (88.7) 34 (89.5)
Mean ± SD 56.50 ± 10.86 51.43 ± 10.99 54.47 ± 10.90 0.272 55.35  ± 11.01 54.47  ± 10.90 0.541
Gender
Males 31 (64.6) 11 (78.6) 23 (60.5) 0.528 42 (67.7) 23 (60.5) 0.463
Females 17 (35.4) 3 (21.4) 15 (39.5) 20 (32.3) 15 (39.5)
Risk factors of stroke
Smoker 20 (41.7) 6 (42.9) 15 (39.5) 0.968 26 (41.9) 15 (39.5) 0.808
DM 25 (52.1) 4 (28.6) 20 (52.6) 0.257 29 (46.8) 20 (52.6) 0.570
HTN 35 (72.9) 5 (35.7) 21 (55.3) 0.028* 40 (64.5) 21 (55.3) 0.357
Hyperlipidemia 12 (25) 5 (35.7) 13 (34.2) 0.626 17 (27.4) 13 (34.2) 0.472
NIHH score
Mild 25 (52.1) 7 (50) 17 (44.7) 0.729 32 (51.6) 17 (44.7) 0.338
Moderate 21 (43.8) 7 (50) 17 (44.7) 28 (45.2) 17 (44.7)
Severe 7 (4.2) 0 (0) 4 (10.5) 2 (3.2) 4 (10.5)
Duplex atherosclerotic scoring
Normal 7 (14.6) 5 (35.7) 9 (23.7) 0.335 12 (19.4) 9 (23.7) 0.614
Mild 25 (52.1) 4 (28.6) 15 (39.5) 29 (46.8) 15 (39.5)
Moderate 11 (22.9) 2 (14.3) 6 (15.8) 13 (21) 6 (15.8)
Severe 5 (10.4) 3 (21.4) 8 (21.1) 8 (12.9) 8 (21.1)
CRP levels
Normal ≤ 5 mg/L 6 (12.5) 3 (21.4) 23 (60.5)  < 0.001* 9 (14.5) 23 (60.5)  < 0.001*
Abnormal > 5 mg/L 42 (87.5) 11 (78.6) 15 (39.5) 53 (85.5) 15 (39.5)
Mean ± SD 26.60 ± 18.54 20.39 ± 20.11 8.34 ± 10.81  < 0.001* 25.20 ± 18.92 8.34 ± 10.81  < 0.001*
  1. DM Diabetes Mellitus, HTN hypertension, SD standard deviation, NIHSS National Institutes of Health Stroke Scale
  2. *p Value ≤ 0.05 is statistically significant