A study of nasal epithelial cell gene expression in a sample of mild to severe asthmatic children and healthy controls

Egyptian Journal of Medical Human Genetics

Table 3 Expression of nasal epithelial cell genes in the studied groups

Variables	Control group (N = 30)	Mild persistent (N = 34)	Moderate persistent (N = 26)	Severe persistent (N = 10)	Kruskal–Wallis test (χ²)	P
Variables	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE	Kruskal–Wallis test (χ²)	P
TMEM178	6.251 ± 0.149	4.703 ± 0.12 (0.75 fold)	3.521 ± 0.181 (0.56 fold)	1.293 ± 0.295 (0.2 fold)	77.59	p1 = 0.001* p2 = 0.001* p3 = 0.001* p4 = 0.001* p5 = 0.001* p6 = 0.001*
FKBP5	0.47 ± 0.049	0.496 ± 0.047 (1.055 fold)	0.608 ± 0.059 (1.29 fold)	0.64 ± 0.087 (1.36 fold)	5.38	p1 = 0.747 p2 = 0.063 p3 = 0.104 p4 = 0.121 p5 = 0.17; p6 = 0.89
CLCA1	0.026 ± 0.006	0.047 ± 0.005 (1.81 fold)	0.049 ± 0.006 (1.88 fold)	0.064 ± 0.014 (2.46 fold)	13.58	p1 = 0.002* p2 = 0.003* p3 = 0.046* p4 = 0.77 p5 = 0.28; p6 = 0.34
SERPINB2	0.067 ± 0.01	2.01 ± 0.13 (30 fold)	2.33 ± 0.22 (34.78 fold)	2.66 ± 0.28 (39.7 fold)	63.86	p1 = 0.001* p2 = 0.001* p3 = 0.001* p4 = 0.45 p5 = 0.06; p6 = 0.42
Periostin	0.022 ± 0.005	0.061 ± 0.016 (2.77 fold)	0.115 ± 0.039 (5.23 fold)	0.097 ± 0.038 (4.41 fold)	19.3	p1 = 0.001; p2 = 0.001 p3 = 0.006*; p4 = 0.17 p5 = 34; p6 = 0.97

p1: mild and control, p2: moderate and control, p3: severe and control, p4: mild and moderate, p5: mild and severe, p6: moderate and severe, TMEM178: transmembrane protein 178, CLCA1: chloride pathway, calcium activated family member 1, SERPINB2: serpin peptidase inhibitor, clade B, member 2
*P < 0.05 is significant