Differential expression of microRNAs targeting genes associated with the development of high-grade gliomas

Egyptian Journal of Medical Human Genetics

Table 2 Statistically significant (p < 0.05) changes in gene and microRNA expression in high-grade tissue relatively healthy

Gene	Median FC	Regulatory microRNA	Median FC	Correlation Spearmen
EGFR	2.42	hsa-miR-21-5p	2.9	r = 0.38, p = 0.044*
		hsa-miR-155-5p	3	r = 0.34, p = 0.08*
		hsa-miR-122-5p	0.6	r = 0.15, p = 0.44
SMAD4	0.9	hsa-miR-155-5p	3	r = − 0.2, p = 0.3
SMAD7	0.31	hsa-miR-330-3p	0.09	r = 0.62, p = 4e−04*
SMAD7	0.31	hsa-miR-21-5p	2.9	r = − 0.35, p = 0.067
SMO	1.3	hsa-miR-324-5p	0.48	r = − 0.4, p = 0.033*
SMO	1.3	hsa-miR-330-3p	0.09	r = − 0.05, p = 0.8
HIF1A	1.79	hsa-miR-330-3p	0.09	r = − 0.25, p = 0.2
		hsa-miR-21-5p	2.9	r = 0.29, p = 0.12
		hsa-miR-22-3p	0.81	r = − 0.01, p = 0.96
		hsa-miR-107	0.55	r = − 0.29, p = 0.13
		hsa-miR-155-5p	3	r = 0.48, p = 0.01*
EGLN1	0.66	hsa-miR-21-5p	2.9	r = − 0.26, p = 0.18
EGLN3	0.56	hsa-miR-122-5p	0.6	r = − 0.27, p = 0.16