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Table 2 List of candidate genes involved in NPH

From: Cerebrospinal fluid biomarkers and genetic factors associated with normal pressure hydrocephalus and Alzheimer’s disease: a narrative review

Gene

Relation

References

CFAP43

Nonsense gene mutation in NPH

[58]

A1R and A2AR

Low expression in NPH

[61]

Transthyretin

Low expression in NPH

[64]

AMPP

High expression in NPH

[64]

SFMBT1

Copy loss in NPH

[71,72,73]

C9ORF72

Full or intermediate (20–30 repeats) expansion

[84]

APOE

ApoE3/3 genotype associated with gait improvement in NPH

[93,94,95]

ATP1A3

Gene mutation in NPH

[99, 100]

PSENEN

Involved in AD and NPH pathophysiology

[102]

APLP1

Involved in AD and NPH pathophysiology

[103]