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Fig. 4 | Egyptian Journal of Medical Human Genetics

Fig. 4

From: Chronic myeloid leukemia: cytogenetics and molecular biology’s part in the comprehension and management of the pathology and treatment evolution

Fig. 4

Signaling pathways involved in p210 (the main protein) oncogenesis (Created on BioRender). Comment: Signalization is initiated by the TKR dimerization and activation of itself by autophosphorylation which generates the recruitment of adapter proteins [such as GRB-2, docking protein (DOK), CRKL, CRK and Casitas B-lineage Lymphoma protein (CBL)] necessary for protein to protein interactions and signal transduction. TKRs regulate several pathways and among the most important are RAS/MAPK, PI3K/AKT and JAK2/STAT

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