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Fig. 5 | Egyptian Journal of Medical Human Genetics

Fig. 5

From: Chronic myeloid leukemia: cytogenetics and molecular biology’s part in the comprehension and management of the pathology and treatment evolution

Fig. 5

Schematic representation of the kinase domain of BCR-ABL kinase showing the approximate location of resistant mutations reported in tyrosine kinase inhibitors studies. P-loop phosphate-binding loop, ATP BD ATP-binding domain, SH2 Src Homology 2 domain, Substrate BR Substrate-binding region, A-loop Activation loop [30, 33, 36, 44, 73, 74]

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