Table 1 Cytogenetic variants of CML and examples of some additional chromosomal abnormalities in Ph+ cells and Ph− cells
Cytogenetic variants | |
Complex translocations including chromosome 9, 22 and at least one additional chromosome | |
Simple translocations of 22ql l-qter to a chromosome other than 9 | |
Ph chromosome which has lost its typical 22q− aspect | |
Ph negative (Ph−) | |
Additional chromosomal abnormalities | |
Ph+ cells | Ph− cells |
Major pathway | trisomy 8 |
trisomy 8 | t(6; 9) (p21; q34.1) |
+der (22) t(9; 22) | + mar |
i (17) (q10) | |
trisomy 19 | |
Minor pathway | |
t(3; 21) (q26; q22) | |
(− 7, − 17, + 17, + 21, and − Y) |