Association of OPRM1 with addiction: a review on drug, alcohol and smoking addiction in worldwide population

Egyptian Journal of Medical Human Genetics

Table 1 Association and pathway studies of drug addiction

S No	Population/ethnicity	Addiction-dependent cases				Controls	Genes				Reference
		OD/HD	CD	MD	AmD		OPRM1		OPRK1	OPRD1
1	Swedish	139				170	√				[10]
2	Asian	473					√				[6]
3	Asian	87				82	√				[11]
4	African Americans	336	503							√	[12]
5	European Americans	1007	336							√	[12]
6	Caucasian				162		√				[13]
7	Asian (Manipur, India)	132				147	√				[14]
8	Mix (7)	79	202			116	√				[15]
9	African Americans	33	125			51	√				[16]
10	Asian (Japanese)				128	232	√				[17]
11	European Americans	412				184	√		√	√	[18]
12	African Americans	202				167	√		√	√	[19]
13	Pakistan	100				100	√				[20]
14	European Americans	83				832	√		√	√	[21]
15	European Americans	91	171			338	√				[22]
16	European Americans	111	225			443			√	√	[23]
17	European Americans	21								√	[24]
18	Caucasian	56				83		√			[25]
19	Caucasian	236				84		√			[26]
	African Americans	74				34		√			[26]
20	Asian (China)	145				48		√			[27]
21	Iran	100				100		√	√	√	[28]
22	Han Chinese (Taiwanese)	72						√	√	√	[29]
23	European Americans			117		76		√			[30]
24	Malaysians Malays	459				543				√	[31]

The table depicts the association and pathway studies of drug addiction cases and dependent cases which have been analysed for OPRM1, OPRK1 and OPRD1 genes studies from different countries