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Egyptian Journal of Medical Human Genetics

Table 5 OPRM1 variants allele frequency and genotype frequency in different worldwide population

From: Association of OPRM1 with addiction: a review on drug, alcohol and smoking addiction in worldwide population

S. No

Author

Location

Population

rsID

Controls

Patients

Substance

Allele frequency

Genotype frequency

A

G

OR

P value

OR

P value

1

[32]

Europe

Turkish

rs1799971

83

103

General substance

0.839

0.084

2.07

0.031

2.32

0.027

96

Opioid

–

–

–

–

2.217

0.081

96

Cocaine

–

–

–

–

0.635

0.484

2

[10]

Europe

Swedish

rs1799971

120

67

Heroin

0.828

0.172

2.72**

0.0025

2.97

0.0031

3

[36]

Europe

European Ancestry

rs1799971

–

–

Substance dependence

–

–

–

–

0.90

0.952**

4

[34]

Asia

Indonesian

rs1799971

–

158

Opioid

0.396

0.604

0.029*

1.659**

1.19

0.092

5

[20]

Asia

Pakistan

rs1799971

100

100

Opioid

0.74

0.26

–

–

3.06(GG)

0.016

6

[37]

Europe

Caucasian European

rs1799971

–

65

Heroin

–

–

–

–

0.061*

0.013

7

[35]

North America

European American

rs62638690

–

1377

Heroin/cocaine

©

0.99 (F)

0.47

0.02

0.94

0.796

rs17174794

–

C

0.38 G

1.49

0.19

African American

rs17174801

–

A

0.9 G

1.14

0.65

0.94

0.74

rs1799971

–

 

2.62**

0.57

0.57

8

[33]

European

UAE

rs1799971

262

512

SUD

–

–

–

–

0.78

0.12

9

[39]

Europe

Bulgarian

rs1799971

3293

Heroin

Roma

–

0.202

–

0.0009

–

–

Non-Roma

–

0.138

–

–

–

–

10

[40]

Europe

Spanish

rs1799971

763 women (465)

Men (298)

Alcohol

Women

    

0.55

0.049

 

Men

–

–

2.25

0.046

–

0.280

11

[41]

Europe

Caucasian

rs1799971

295

Alcohol

–

–

–

–

–

0.056

12

[49]

  

rs1799971

9613

Alcohol

–

–

–

–

1.261

0.042

13

[46]

Europe

Finnish

rs1799971

        

14

[47]

Asia

Korean

rs1799971

140

112

Alcohol

0.603

0.397

1.40

0.105

1.21

0.045

15

[33]

Europe

UAE

rs1799971

262

512

SUD

0.189

0.154

0.78

0.12

–

–

Egypt Arabs

rs1799971

0.007

0.052*

0.73

0.54

–

–

Combine of UAE& Egypt Arabs

rs1799971

0.17

0.13

0.73

0.04

–

–

16

[40]

Europe

Spanish

rs1799971

763 (Unrelated Subject)

Smoking

–

–

–

–

–

0.716

17

[49]

Europe + Asia

Caucasian + Asian

rs1799971

3313

Nicotine dependence

–

–

1.000

0.999

1.261

0.042

18

[50]

Europe

Caucasian

rs1799971

62

Cigarette craving

–

–

–

–

–

0.008

19

[2]

Europe

Caucasian

rs1799971

–

Smoking

–

–

–

–

3.26**

0.00*

  1. This table explains the OPRM1 variants allele frequency and genotyped frequency in different worldwide population compared to patients and controls
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