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Table 5 OPRM1 variants allele frequency and genotype frequency in different worldwide population

From: Association of OPRM1 with addiction: a review on drug, alcohol and smoking addiction in worldwide population

S. No Author Location Population rsID Controls Patients Substance Allele frequency Genotype frequency
A G OR P value OR P value
1 [32] Europe Turkish rs1799971 83 103 General substance 0.839 0.084 2.07 0.031 2.32 0.027
96 Opioid 2.217 0.081
96 Cocaine 0.635 0.484
2 [10] Europe Swedish rs1799971 120 67 Heroin 0.828 0.172 2.72** 0.0025 2.97 0.0031
3 [36] Europe European Ancestry rs1799971 Substance dependence 0.90 0.952**
4 [34] Asia Indonesian rs1799971 158 Opioid 0.396 0.604 0.029* 1.659** 1.19 0.092
5 [20] Asia Pakistan rs1799971 100 100 Opioid 0.74 0.26 3.06(GG) 0.016
6 [37] Europe Caucasian European rs1799971 65 Heroin 0.061* 0.013
7 [35] North America European American rs62638690 1377 Heroin/cocaine © 0.99 (F) 0.47 0.02 0.94 0.796
rs17174794 C 0.38 G 1.49 0.19
African American rs17174801 A 0.9 G 1.14 0.65 0.94 0.74
rs1799971   2.62** 0.57 0.57
8 [33] European UAE rs1799971 262 512 SUD 0.78 0.12
9 [39] Europe Bulgarian rs1799971 3293 Heroin Roma 0.202 0.0009
Non-Roma 0.138
10 [40] Europe Spanish rs1799971 763 women (465)
Men (298)
Alcohol Women      0.55 0.049
  Men 2.25 0.046 0.280
11 [41] Europe Caucasian rs1799971 295 Alcohol 0.056
12 [49]    rs1799971 9613 Alcohol 1.261 0.042
13 [46] Europe Finnish rs1799971         
14 [47] Asia Korean rs1799971 140 112 Alcohol 0.603 0.397 1.40 0.105 1.21 0.045
15 [33] Europe UAE rs1799971 262 512 SUD 0.189 0.154 0.78 0.12
Egypt Arabs rs1799971 0.007 0.052* 0.73 0.54
Combine of UAE& Egypt Arabs rs1799971 0.17 0.13 0.73 0.04
16 [40] Europe Spanish rs1799971 763 (Unrelated Subject) Smoking 0.716
17 [49] Europe + Asia Caucasian + Asian rs1799971 3313 Nicotine dependence 1.000 0.999 1.261 0.042
18 [50] Europe Caucasian rs1799971 62 Cigarette craving 0.008
19 [2] Europe Caucasian rs1799971 Smoking 3.26** 0.00*
  1. This table explains the OPRM1 variants allele frequency and genotyped frequency in different worldwide population compared to patients and controls