Association of Keap1 (rs11085735) polymorphism and lncRNA MEG3 hypermethylation status with the risk of preeclampsia

Egyptian Journal of Medical Human Genetics

Table 2 Distribution of Keap1 and Lnc RNA MEG3 genotypes in patients with preeclampsia, severe- and mild preeclampsia patients and controls

Parameters	All preeclamptic patients	Severe preeclampsia patients	Mild preeclampsia patients	Controls
	N = 75	N = 28	N = 47	N = 75
Keap1 genotypes
AA	5 (6.7%)	1 (3.6%)	4 (8.5%)	7 (9.3%)
AC	0 (0.0%) χ² = 2.9; p = 0.08	0 (0.0%) χ² = 0.67; p = 0.4	43 (91.5%)	5 (6.7%)
CC	70 (93.3%) χ² = 0.5; p = 0.4	27 (96.4%) χ² = 1.1; p = 0.2	0 (0)	63 (84.0%)
Keap1 alleles
A	8 (5.3%)	2 (3.6%)	8 (8.5%)	19 (12.7%)
C	142 (94.7%) χ² = 5.1; p = 0.02	54 (96.4%) χ² = 3.7; p = 0.055	86 (91.5%) χ² = 2.3; p = 0.006	131 (87.3%)

	N = 50	N = 22	N = 28	N = 50
Lnc RNA MEG3 genotypes
UU	0 (0.0%)	0 (0.0%)	0 (0%)	1 (2.0%)
UM	47 (94.0%) χ² = 0.95; p = 0.3	19 (86.4%) χ² = 0.38; p = 0.5	28 (100)	49 (98.0%)
MM	3 (6.0%) χ² = 4.0; p = 0.04	3 (13.6%) χ² = 4.0; p = 0.04	0 (0)	0 (0.0%)

*Overall χ² comparing Keap1 genotypes between all preeclamptic patients and controls was 5.7; p = 0.05
**Overall χ² comparing Keap1 genotypes between severe preeclamptic patients and controls was 0.3; p = 0.2
***Overall χ² comparing Keap1 genotypes between mild preeclamptic patients and controls was 3.3; p = 0.18
****Overall χ² comparing Keap1 genotypes between mild- and severe- preeclampsia was 0.68; p = 0.4
^#Overall χ² comparing lncRNA MEG3 genotypes between all preeclamptic patients and controls was 4.0; p = 0.1
^##Overall χ² comparing lncRNA MEG3 genotypes between severe preeclamptic patients and controls was 7.4; p = 0.02
^###Overall χ² comparing lncRNA MEG3 genotypes between mild preeclamptic patients and controls was 0.57; p = 0.45
^####Overall χ² comparing lncRNA MEG3 genotypes between mild- and severe preeclampsia was 4.1; p = 0.044