Interleukin-4 gene intron 3 VNTR polymorphism in adult acute myeloid leukemia

Safwat, Nesma A.; Najjar, Marwa R. El; Saeed, Alia M.; Mohamed, Haydi S.

doi:10.1186/s43042-022-00253-5

Egyptian Journal of Medical Human Genetics

Table 6 Correlation of overall survival with other variables

From: Interleukin-4 gene intron 3 VNTR polymorphism in adult acute myeloid leukemia

		Total N	N of events	OS (months)		95% CI		Survival at				Log Rank test
		Total N	N of events	Mean	SE	Lower	Upper	1 m. (%)	3 m. (%)	6 m. (%)	12 m. (%)	X²	P value	Sig
Overall		50	26	12.346	1.565	9.279	15.412	76.0	55.3	50.6	43.4	–	–-	–
Age	≤ 45 yrs	24	10	14.719	2.226	10.355	19.082	87.5	56.6	56.3	56.3	1.817	0.178	NS
Age	> 45 yrs	26	16	10.379	2.082	6.298	14.46	65.4	46.2	46.2	33.0	1.817	0.178	NS
TLC	TLC < 20	27	13	13.31	2.100	9.195	17.425	77.8	62.6	58.4	45.4	0.481	0.488	NS
TLC	TLC ≥ 20	23	13	11.242	2.308	6.718	15.766	73.9	46.6	41.4	41.4	0.481	0.488	NS
HGB	< 7.5	26	11	14.399	2.169	10.148	18.649	76.9	68.8	59.6	52.2	1.587	0.208	NS
HGB	> 7.5	24	15	10.292	2.163	6.053	14.531	75.0	41.7	41.7	34.7	1.587	0.208	NS
PLT	< 40	27	15	10.972	2.168	6.724	15.221	74.1	54.6	44.6	35.7	0.722	0.395	NS
PLT	≥ 40	23	11	13.638	2.265	9.199	18.077	78.3	56.5	56.5	50.2	0.722	0.395	NS
PB blasts	< 32	26	14	12.11	2.112	7.971	16.249	73.1	61.1	52.4	39.3	0.013	0.910	NS
PB blasts	> 32	24	12	12.725	2.29	8.237	17.213	79.2	48.9	48.9	48.9	0.013	0.910	NS
Initial aspirate	< 69	25	10	14.989	2.191	10.694	19.283	80.0	67.8	63.2	55.3	2.517	0.113	NS
Initial aspirate	> 69	25	16	9.708	2.101	5.591	13.826	72.0	42.7	37.9	31.6	2.517	0.113	NS
Extramedullary involvement	Negative	31	17	11.876	1.942	8.07	15.681	77.4	57.0	49.4	39.6	0.124	0.725	NS
Extramedullary involvement	Positive	19	9	13.474	2.55	8.476	18.471	73.7	52.6	52.6	52.6	0.124	0.725	NS
Diagnosis	M0	2	2	1.5	0.5	0.52	2.48	50.0	0.0	0.0	0.0	5.682	0.338	NS
	M1	8	3	9.7	2.397	5.002	14.398	75.0	60.0	60.0	60.0
	M2	27	15	11.601	2.112	7.461	15.74	74.1	51.0	47.1	40.3
	M3	3	1	20	3.266	13.599	26.401	66.7	66.7	66.7	66.7
	M4	8	4	13.5	3.742	6.166	20.834	87.5	62.5	50.0	50.0
	M7	2	1	3.5	1.768	0.035	6.965	50.0	50.0	50.0	50.0
HLA-DR	Negative	8	2	19.025	3.054	13.038	25.012	87.5	87.5	87.5	70.0	2.942	0.086	NS
HLA-DR	Positive	42	24	11.085	1.702	7.75	14.42	73.8	48.9	43.4	38.6	2.942	0.086	NS
CD34	Negative	11	4	16.073	3.138	9.922	22.224	81.8	72.7	72.7	58.2	1.414	0.234	NS
CD34	Positive	39	22	11.263	1.764	7.806	14.721	74.4	50.0	44.1	39.2	1.414	0.234	NS
MPOX	Negative	8	4	12.875	3.939	5.155	20.595	75.0	50.0	50.0	50.0	0.000	0.988	NS
MPOX	Positive	42	22	12.285	1.698	8.956	15.613	76.2	56.3	50.9	42.4	0.000	0.988	NS
PCR product	P1P1	1	0	–	–	–	–	100.0	100.0	100.0	100.0	1.561	0.458	NS
	P2P2	29	14	13.285	2.039	9.289	17.282	72.4	61.9	58.0	46.4
	P1P2	20	12	10.438	2.421	5.693	15.184	80.0	43.1	36.9	36.9

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