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Egyptian Journal of Medical Human Genetics

Table 3 Relation of methylation state of RUNX3 and p16 gene promoters with hepatitis C virus, liver cirrhosis, and hepatocellular carcinoma

From: Relation of the methylation state of RUNX3 and p16 gene promoters with hepatocellular carcinoma in Egyptian patients

 

RUNX3

P value OR (95% CI)

p16

P value OR (95% CI)

Methylated

Unmethylated

Methylated

Unmethylated

Control (n = 30)

16 (53.3%)

14 (46.7%)

 

17 (56.7%)

13 (43.3%)

 

HCV (n = 30)

21 (70%)

9 (30%)

0.187

2.04 (0.71 – 5.89)

15 (50%)

15 (50%)

0.605

0.76 (0.28 – 2.11)

Cirrhosis (n = 30)

21 (70%)

9 (30%)

0.187

2.04 (0.71 – 5.89)

23 (76.7%)

7 (23.3%)

0.105

2.51 (0.83 – 7.64)

HCC (n = 30)

25 (83.3%)

5 (16.7%)

0.016*

4.38 (1.32 – 14.50)

26 (86.7%)

4 (13.3%)

0.014*

4.97 (1.39 – 17.82)

  1. Data are represented as N (%). Comparisons were performed by chi-square test
  2. HCV hepatitis C virus, HCC hepatocellular carcinoma, OR odds ratio, CI confidence intervals
  3. *Indicates significant difference at P < 0.05 compared to the control group
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