Table 3 Genotype and allele frequencies of FTO rs9939609 (T>A) and FTO rs1421085 (T>C) variants in PCOS patients and controls
From: Association of FTO gene variants rs9939609 and rs1421085 with polycystic ovary syndrome
Gene polymorphism | Control | PCOS | Control versus PCOS | |||
|---|---|---|---|---|---|---|
n (%) | n (%) | OR (95% CI) | χ2 | p | ||
FTO rs9939609 Genotype | TT | 29 (29.3) | 47 (48.0) | 2.03 (0.83–4.93) | 2.46 | 0.116 |
|  | TA | 55 (55.6) | 39 (39.8) | 0.44 (0.24–0.81) | 6.96 | 0.008* |
|  | AA | 15 (15.2) | 12 (12.2) | 0.50 (0.20–1.20) | 2.46 | 0.116 |
|  | TT + TA | 84 (84.8) | 86 (87.8) | 1.30 (0.57–2.90) | 0.35 | 0.553 |
|  | TA + AA | 70 (70.7) | 51 (52.0) | 0.45 (0.25–0.81) | 7.24 | 0.007* |
Allele | T | 113 (57.1) | 133 (67.9) | 0.63 (0.42–0.95) | 4.89 | 0.027* |
|  | A | 85 (42.9) | 63 (32.1) | 1.59 (1.05–2.40) |  |  |
|  |  | n = 99 | n = 98 |  |  |  |
FTO rs1421085 Genotype | TT | 32 (32.3) | 28 (28.6) | 1.20 (0.57–2.52) | 0.21 | 0.644 |
|  | TC | 37 (37.4) | 48 (49.0) | 1.48 (0.76–2.90) | 1.36 | 0.244 |
|  | CC | 30 (30.3) | 22 (22.4) | 0.84 (0.40–1.77) | 0.21 | 0.644 |
|  | TT + TC | 69 (69.7) | 76 (77.6) | 1.50 (0.80–2.85) | 1.56 | 0.211 |
|  | TC + CC | 67 (67.7) | 70 (71.4) | 1.20 (0.65–2.20) | 0.33 | 0.567 |
Allele | T | 101 (51.0) | 104 (53.1) | 0.92 (0.62–1.37) | 0.17 | 0.684 |
|  | C | 97 (49.0) | 92 (46.9) | 1.10 (0.73–1.61) |  |  |
|  |  | n = 99 | n = 98 |  |  |  |