Table 2 Significantly differentially expressed genes in smokers as revealed by IPA and as sorted by p value
From: Pathway analysis of smoking-induced changes in buccal mucosal gene expression
NCBI ID | Gene symbol | Gene name | Chr | Molecule type | Expression | Log2 ratio | p value |
|---|---|---|---|---|---|---|---|
Top differentially expressed protein-coding genes | |||||||
26038 | CHD5 | Chromodomain helicase DNA binding protein 5 | 1 | Enzyme | Up | 2.335 | 1.28 × 10–04 |
27344 | PCSK1N | Proprotein convertase subtilisin/kexin type 1 inhibitor | X | Other | Up | 2.45 | 2.72 × 10–04 |
9444 | QKI | QKI, KH domain containing RNA binding | 6 | Other | Down | − 2.484 | 2.97 × 10–04 |
55509 | BATF3 | Basic leucine zipper ATF-like transcription factor 3 | 1 | Transcription regulator | Up | 2.379 | 3.54 × 10–04 |
3570 | IL6R | Interleukin 6 receptor | 1 | Transmembrane receptor | Down | − 2.444 | 3.80 × 10–04 |
51302 | CYP39A1 | Cytochrome P450 family 39 subfamily A member 1 | 6 | Enzyme | Down | − 2.371 | 4.35 × 10–04 |
11075 | STMN2 | stathmin 2 | 8 | Other | Up | 2.786 | 4.65 × 10–04 |
55072 | RNF31 | Ring finger protein 31 | 14 | Enzyme | Up | 2.249 | 4.74 × 10–04 |
9913 | SUPT7L | SPT7 like, STAGA complex subunit gamma | 2 | Transcription regulator | Up | 2.605 | 6.26 × 10–04 |
221823 | PRPS1L1 | Phosphoribosyl pyrophosphate synthetase 1 like 1 | 7 | Kinase | Up | 2.102 | 6.64 × 10–04 |
Top differentially expressed lncRNA genes | |||||||
100505933 | ADD3-AS1 | ADD3 antisense RNA 1 | 10 | Other | Up | 2.075 | 1.42 × 10–03 |
6315 | ATXN8OS | ATXN8 opposite strand lncRNA | 13 | Other | Up | 1.952 | 7.57 × 10–03 |
100506070 | RBFADN | RBFA downstream neighbor | 18 | Other | Up | 1.683 | 9.10 × 10–03 |
100131532 | LOC100131532 | Uncharacterized LOC100131532 | 6 | Other | Up | 2.136 | 1.93 × 10–02 |
25859 | PART1 | Prostate androgen-regulated transcript 1 | 5 | Other | Down | − 0.942 | 3.01 × 10–02 |
100130449 | LOC100130449 | Uncharacterized LOC100130449 | 2 | Other | Down | − 1.603 | 3.52 × 10–02 |
Top differentially expressed pseudogenes | |||||||
388714 | FMO6P | Flavin containing dimethylaniline monoxygenase 6, pseudogene | 1 | Other | Up | 1.778 | 5.11 × 10–03 |
442240 | ZNF259P1 | Zinc finger protein 259 pseudogene 1 | 6 | Other | Up | 2.054 | 5.65 × 10–03 |
228 | ALDOAP2 | ALDOA pseudogene 2 | 10 | Other | Down | − 1.573 | 1.05 × 10–02 |
79986 | ZNF702P | Zinc finger protein 702, pseudogene | 19 | Other | Up | 1.653 | 1.32 × 10–02 |
645,682 | POU5F1P4 | POU class 5 homeobox 1 pseudogene 4 | 1 | Other | Up | 1.521 | 1.46 × 10–02 |
5408 | PNLIPRP2 | Pancreatic lipase related protein 2 (gene/pseudogene) | 10 | Enzyme | Down | − 1.437 | 1.61 × 10–02 |
440915 | POTEKP | POTE ankyrin domain family member K, pseudogene | 2 | Other | Up | 1.62 | 1.93 × 10–02 |
730092 | RRN3P1 | RRN3 pseudogene 1 | 16 | Other | Up | 1.548 | 1.96 × 10–02 |
150244 | ZDHHC8P1 | ZDHHC8 pseudogene 1 | 22 | Other | Up | 1.559 | 2.27 × 10–02 |
202181 | LOC202181 | SUMO interacting motifs containing 1 pseudogene | 5 | Other | Up | 1.932 | 2.67 × 10–02 |