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Table 2 Significantly differentially expressed genes in smokers as revealed by IPA and as sorted by p value

From: Pathway analysis of smoking-induced changes in buccal mucosal gene expression

NCBI ID Gene symbol Gene name Chr Molecule type Expression Log2 ratio p value
Top differentially expressed protein-coding genes
26038 CHD5 Chromodomain helicase DNA binding protein 5 1 Enzyme Up 2.335 1.28 × 10–04
27344 PCSK1N Proprotein convertase subtilisin/kexin type 1 inhibitor X Other Up 2.45 2.72 × 10–04
9444 QKI QKI, KH domain containing RNA binding 6 Other Down − 2.484 2.97 × 10–04
55509 BATF3 Basic leucine zipper ATF-like transcription factor 3 1 Transcription regulator Up 2.379 3.54 × 10–04
3570 IL6R Interleukin 6 receptor 1 Transmembrane receptor Down − 2.444 3.80 × 10–04
51302 CYP39A1 Cytochrome P450 family 39 subfamily A member 1 6 Enzyme Down − 2.371 4.35 × 10–04
11075 STMN2 stathmin 2 8 Other Up 2.786 4.65 × 10–04
55072 RNF31 Ring finger protein 31 14 Enzyme Up 2.249 4.74 × 10–04
9913 SUPT7L SPT7 like, STAGA complex subunit gamma 2 Transcription regulator Up 2.605 6.26 × 10–04
221823 PRPS1L1 Phosphoribosyl pyrophosphate synthetase 1 like 1 7 Kinase Up 2.102 6.64 × 10–04
Top differentially expressed lncRNA genes
100505933 ADD3-AS1 ADD3 antisense RNA 1 10 Other Up 2.075 1.42 × 10–03
6315 ATXN8OS ATXN8 opposite strand lncRNA 13 Other Up 1.952 7.57 × 10–03
100506070 RBFADN RBFA downstream neighbor 18 Other Up 1.683 9.10 × 10–03
100131532 LOC100131532 Uncharacterized LOC100131532 6 Other Up 2.136 1.93 × 10–02
25859 PART1 Prostate androgen-regulated transcript 1 5 Other Down − 0.942 3.01 × 10–02
100130449 LOC100130449 Uncharacterized LOC100130449 2 Other Down − 1.603 3.52 × 10–02
Top differentially expressed pseudogenes
388714 FMO6P Flavin containing dimethylaniline monoxygenase 6, pseudogene 1 Other Up 1.778 5.11 × 10–03
442240 ZNF259P1 Zinc finger protein 259 pseudogene 1 6 Other Up 2.054 5.65 × 10–03
228 ALDOAP2 ALDOA pseudogene 2 10 Other Down − 1.573 1.05 × 10–02
79986 ZNF702P Zinc finger protein 702, pseudogene 19 Other Up 1.653 1.32 × 10–02
645,682 POU5F1P4 POU class 5 homeobox 1 pseudogene 4 1 Other Up 1.521 1.46 × 10–02
5408 PNLIPRP2 Pancreatic lipase related protein 2 (gene/pseudogene) 10 Enzyme Down − 1.437 1.61 × 10–02
440915 POTEKP POTE ankyrin domain family member K, pseudogene 2 Other Up 1.62 1.93 × 10–02
730092 RRN3P1 RRN3 pseudogene 1 16 Other Up 1.548 1.96 × 10–02
150244 ZDHHC8P1 ZDHHC8 pseudogene 1 22 Other Up 1.559 2.27 × 10–02
202181 LOC202181 SUMO interacting motifs containing 1 pseudogene 5 Other Up 1.932 2.67 × 10–02
  1. Chr, chromosome; log2 ratio, log2 fold change ratio of the gene expression between 2 groups