From: An actualized screening of schizophrenia-associated genes
References | Ethnicity | Total sample | No. of case/control | Mean age (case/control) | % Men (case/control) | Genotyping method | Gene | Polymorphism | Associated/no associated |
---|---|---|---|---|---|---|---|---|---|
Mazaheri and Saadat [29] | Iranian | 726 | 363/363 | 41.4±13.1/39.7±11.1 | 73.8%/73.8% | PCR Assay | ACE | I/D | Yes (insertion with women) |
Ozsoy et al. [32] | Turkish | 252 | 100/152 | 39.11 ± 10.08/47.74 ± 13.26 | 55%/60.5% | PCR–RFLP | AUTS2 | rs6943555 | Yes |
Zhang et al. [37] | Chinese Han | 2240 | 1086/1154 | 34.24 ± 12.26/ | / | Mass ARRAY/ | C3 | rs11569562 | Yes (rs11569514) |
 |  |  |  | 36.47 ± 10.93 |  | PCR | I | rs344555 |  |
 |  |  |  |  |  |  | I | rs2241393 |  |
 |  |  | I |  |  |  | rs11569514 |  |  |
 |  |  |  |  |  |  | I | rs445750 |  |
Fu et al. [16] | Chinese Han | 1536 | 761/775 | 34.61 ± 12.02/ | 58.2%/56.2% | MALDI-TOF–MS technology | CACNA2D2 | rs12496815 | Yes (rs45536634) |
 |  |  |  | 34.74 ± 11.41 |  |  | I | rs3806706 |  |
 |  |  |  |  |  |  | I | rs45536634 |  |
Chu et al. [12] | Taiwan | 515 | 248/267 | 39.22 ± 10.64/ | 56%/81.6% | SNPlex genotyping system | DAO | rs3741775 | No |
 |  |  |  | 36.13 ± 11.95 |  |  |  |  |  |
Chu et al. [12] | Taiwan | 515 | 248/267 | 39.22 ± 10.64/ | 56%/81.6% | SNPlex genotyping system | DAOA | rs3916956 | Yes (rs778292, rs3918342, rs1421292) |
 |  |  |  | 36.13 ± 11.95 |  |  | I | rs2391191 |  |
 |  |  |  |  |  |  | I | rs778292 |  |
 |  |  |  |  |  |  | I | rs3918342 |  |
 |  |  |  |  |  |  | I | rs1421292 |  |
Fatima et al. [15] | Pakistani | 300 | 150/150 | 34.07 ± 9.5/ | 65.3%/61.3% | PCR/PCR–RFLP | DISC | rs1417584 | Yes (rs1417584) |
 |  |  |  | 33.8 ± 10.6 |  |  | I | rs1954175 |  |
 |  |  |  |  |  |  | I | rs821616 |  |
 |  |  |  |  |  |  | I | rs113012343 |  |
He et al. [18] | Chinese | 484 | 248/236 | 54.39 ± 13.39/ | 64.5%/65.6% | MassARRAY | DISC1 | rs821616 | Yes (rs821616, |
 |  |  |  | 56.11 ± 12.91 |  |  | I | rs821597 | rs821597) |
Zhang et al. [39] | Northeast Chinese Han | 630 | 306/324 | 44.6 ± 7.3/ | 50.3%/48.5% | PCR | DRD2 | rs7116768 | No |
 |  |  |  | 45.3 ± 15.9 |  |  | I | rs1799732 |  |
Pae et al. [33] | Korean | 1509 | 908/601 | 38.9Â /33.7 | 50.5%/50.9% | Pyrosequencer | DTNBP1 | rs3213207 | Yes (rs760761, rs2619522) |
 |  |  |  |  |  |  | I | rs1011313 |  |
 |  |  |  |  |  |  | I | rs760761 |  |
 |  |  |  |  |  |  | I | rs2619522 |  |
Gao et al. [28] | Northern Chinese | 602 | 281/321 | 41.1 ± 7.1/ | 50.8%/48.2% | PCR | EFHD2 | rs2473357 | Yes (rs2473357) |
 | Han |  |  | 43.7 ± 7.4 |  |  | I | rs71631726 |  |
 |  |  |  |  |  |  | I | rs140124965 |  |
 |  |  |  |  |  |  | I | rs10927785 |  |
Al-Eitan et al. [7] | Jordan | 380 | 185/195 | 45 .9 ± 12.6/ | 100%/100% | PCR | ERBB4 | rs839523 (G/A) | Yes (rs839523) |
 |  |  |  | 31.4 ± 8.1 |  |  | I | rs3748962 (A/G) |  |
Heidari Nia et al. [19] | Iranian | 390 | 190/200 | 36.48 ±10.52/36.40±10.88 | / | Tetra-ARMS-PCR | GABRB2 | rs12187676(G/C) | Yes (rs1816072) |
 |  |  |  |  |  |  | I | rs1816072 (T/C) |  |
Yang et al. [40] | Chinese | 1504 | 893/611 | 50.4 ± 13.4/ | 56.4%/54.5% | PCR | GLRX5 | rs1007814 | Yes (rs1007814) |
 |  |  |  | 42.0 ± 9.9 |  |  |  |  |  |
Kang et al. [23] | Korean | 598 | 218/380 | 42.2 ± 10.6/ | / | PCR | GRIA1 | rs1428920 | Yes (rs1428920, |
 |  |  |  | 44.3 ± 6.3 |  |  | I | rs1552834 | rs2926835) |
 |  |  |  |  |  |  | I | rs1422889 |  |
 |  |  |  |  |  |  | I | rs10035143 |  |
 |  |  |  |  |  |  | I | rs2926835 |  |
Ren et al. [36] | Chinese | 2068 | 1034/1034 | 45.06 ± 12.88/ | 60.4%/56.8% | MassARRAY | GRIK4 rs79526501 | No |  |
 |  |  |  | 34.06 ± 10.0 |  | Sequenom | I | rs4582985 |  |
 |  |  |  |  |  |  | I | rs11218016 |  |
 |  |  |  |  |  |  | I | rs6589847 |  |
 |  |  |  |  |  |  | I | rs56275759 |  |
Norton et al. [31] | European & American | 1390 | 674/716 | 44.5 ± 14.6/ | 71.5%/63.6% | Sequenom | GRM3 | rs187993 | No |
 |  |  |  | 41.5 ± 11.5 |  | MassARRAY | I | rs13242038 |  |
 |  |  |  |  |  | PCR | I | rs917071 |  |
 |  |  |  |  |  |  | I | rs6465084 |  |
 |  |  |  |  |  |  | I | rs2228595 |  |
 |  |  |  |  |  |  | I | rs1468412 |  |
 |  |  |  |  |  |  | I | rs3804100 |  |
Raffa et al. [35] | Tunisian | 261 | 138/123 | 32.67 ± 7.44/ | 86.9%/80.4% | PCR | GSTs | GSTM1 | Yes (GSTT1) |
 |  |  |  | 31.28 ± 5.28 |  |  | I | GSTT1 |  |
Kim et al. [25] | Korean | 512 | 278/234 | 42.91 ± 10.91/ | 67.9%/41% | SeqMan II software | HDAC | HDAC3 (rs2530223) | Yes (HDAC3, HDAC4) |
 |  |  |  | 36.06 ± 6.08 |  |  | I | HDAC4 (rs1063639) |  |
 |  |  |  |  |  |  | I | HDAC10 (rs155048) |  |
Kowalczyk et al. [26] | Polish | 1080 | 401/679 | 41.3 ± 12.4/ | 59.6%/52.8% | PCR–RFLP | HSPA1A | rs1008438 | No |
 |  |  |  | 40.4 ± 8.7 |  | TaqMan | I | rs562047 |  |
Kowalczyk et al. [27] | Polish | 901 | 377/524 | 41.1 ± 12.3/ | 59.4%/55.34 | PCR–RFLP/TaqMan Assays | HSPA1B | rs6457452 | No |
 |  |  |  | 39.8 ± 9.1 |  |  | I | rs2763979 |  |
 |  |  |  |  |  |  | I | rs539689 |  |
 |  |  |  |  |  |  | I | rs9281590 |  |
Kowalczyk et al. [26] | Polish | 1080 | 401/679 | 41.3 ± 12.4/ | 59.6%/52.8% | PCR–RFLP | HSPA1L | rs2075800 | No |
 |  |  |  | 40.4 ± 8.7 |  | TaqMan |  |  |  |
Jemli et al. [21] | Tunisian | 391 | 225/166 | 39.7 ± 10.02/ | 77.7%/61.4% | PCR–RFLP | IFNGR2 | Q64R(Gln64Arg) | Yes (Men) |
 |  |  |  | 28.37 ± 8.44 |  |  |  |  |  |
Philibert et al. [34] | European, African-American, Hispanic, Asian | 565 | 206/359 | 39.8 ± 10.8/ | 63.5%/50.6% | Flurescent Primer | MTHFR | C677T | No |
 |  |  |  |  |  | Probe |  |  |  |
Harada et al. [17] | Japanese | 336 | 102/234 | 46.9 ± 14.2/ | 59.8%/70.1% | PCR | NQO2 | I/D | Yes (Deletion) |
 |  |  |  | 46.4 ± 9.1 |  |  |  |  |  |
He et al. [18] | Chinese | 484 | 248/236 | 54.39 ± 13.39/ | 64.5%/65.6% | MassARRAY | NRG1 rs3924999 | Yes (rs3924999) |  |
 |  |  |  | 56.11 ± 12.91 |  |  |  |  |  |
Yue et al. [42] | Chinese Han | 1506 | 768/738 | 33.5 ± 8.7/ | 46.8%/48.5% | TaqMan | NRXN1 | rs10490168 | Yes (rs10490168, rs2024513, rs13382584, |
 |  |  |  | 32.2 ± 6.4 |  |  | I | rs2024513 | rs1558852) |
 |  |  |  |  |  |  | I | rs10174398 |  |
 |  |  |  |  |  |  | I | rs10195460 |  |
 |  |  |  |  |  |  | I | rs13382584 |  |
 |  |  |  |  |  |  | I | rs1558852 |  |
Ding et al. [13] | Chinese Han | 528 | 264/264 | 37.44 ± 11.04/ | 58.3%/55.3% | PCR–RFLP | OPRM1 | rs1799971 | Yes (rs1799971 |
 |  |  |  | 36.38 ± 12.27 |  |  | I | rs2075572 | rs2075572) |
 |  |  |  |  |  |  | I | rs648893 |  |
 |  |  |  |  |  |  | I | rs671531 |  |
Yenilmez et al. [41] | Turkish | 250 | 150/100 | / | / | PCR | PAI-1 | 4G/5G (I/D) | No |
Fatemi et al. [14] | Caucasian, African | 1482 | 878/604 | / | / | TaqMan | PDE4B | rs1354064 | Yes (rs1354064, |
 | American |  |  |  |  |  | I | rs4320761 | rs4320761, rs1040716, rs910694, rs1321177, rs2144719, rs783038, rs599381 |
 |  |  |  |  |  |  | I | rs1040716 |  |
 |  |  |  |  |  |  | I | rs910694 |  |
 |  |  |  |  |  |  | I | rs1321177 |  |
 |  |  |  |  |  |  | I | rs2144719 |  |
 |  |  |  |  |  |  | I | rs783038 |  |
 |  |  |  |  |  |  | I | rs599381 |  |
Nadalin et al. [30] | Croatian | 394 | 203/191 | 40.1 ± 8.8/ | 54.6%/45.5% | PCR–RFLP | PPARα | L162V | No |
Bae et al. [9] | Korean | 842 | 449/393 | 44.92/54.62 | 55.7%/56.5% | TaqMan Assay | RANBP9 | rs24023 | No |
 |  |  |  |  |  |  | I | rs442458 |  |
 |  |  |  |  |  |  | I | rs6940759 |  |
 |  |  |  |  |  |  | I | rs204226 |  |
 |  |  |  |  |  |  | I | rs11759518 |  |
 |  |  |  |  |  |  | I | Ins/Supp(rs16724) |  |
Bai et al. [10] | Northeast Chinese Han | 1536 | 761/775 | 34.61 ± 12.02/ | 58.2%/56.1 | Mass ARRAY | RELN | rs1062831 | Yes (rs362746) |
 |  |  |  | 34.74 ± 11.41 |  |  | I | rs3808039 |  |
 |  |  |  |  |  |  | I | rs362746 |  |
 |  |  |  |  |  |  | I | rs736707 |  |
Bermudo-Soriano et al. [11] | Spanish | 593 | 180/413 | 41.95/38.85 | 53.8%/38% | PCR | SAT-1 | -1415Â T/C SNP | No |
Gao et al. [20] | Chinese | 1076 | 448/628 | 36.1 ± 10.2/ | 49.5%/42.9 | PCR/SNPscan | TCF4 | rs1261085 | Yes (rs2958182) |
 |  |  |  | 35.7 ± 9.7 |  |  | I | rs1261084 |  |
 |  |  |  |  |  |  | I | rs8766 |  |
 |  |  |  |  |  |  | I | rs9960767 |  |
 |  |  |  |  |  |  | I | rs2958182 |  |
 |  |  |  |  |  |  | I | rs12966547 |  |
Kang et al. [24] | Korean | 591 | 286/305 | 42.8 ± 10.8/ | 66.7%/48.1% | PCR | TLR2 | rs3804099 (Asn199Asn) | Yes (rs380499, |
 |  |  |  | 36.6/6.8 |  |  | I | rs3804100 (Ser450Ser) | Rs3804100) |
Gao et al. [22] | Chinese Han | 1986 | 1034/952 | 49.44 ± 17.95/ | 64.7%/51.2% | TaqMan | VEGFA | rs699947 | No |
 |  |  |  | 34.45 ± 10.12 |  |  | I | rs25648 |  |
 |  |  |  |  |  |  | I | rs833070 |  |
 |  |  |  |  |  |  | I. rs3024997 | rs3024997 |  |
 |  |  |  |  |  |  | I | rs10434 |  |
Zhang et al. [8] | Northwest | 893 | 360/533 | 37.2 ± 10.4/ | 49.1%/43.5% | PCR | VRK2 | rs2312147 | Yes (rs3732136) |
 | Chinese Han |  |  | 35.6 ± 11.2 |  |  | I | rs1051061 |  |
 |  |  |  |  |  |  | I | rs2043890 |  |
 |  |  |  |  |  |  | I | rs3732136 |  |
Taghipour et al. [38] | Iran | 721 | 361/360 | 41.9 ± 13.5/40.6 ± 13.2/ | 72.3%/74.1 | SNP Alyze (TM) software | XPC | Ala499Val | Yes (Haplotype Val-Lys) |
 |  |  |  |  |  |  | I | PAT |  |
 |  |  |  |  |  |  | I | Lys939Gln |  |