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Table 2 The genetic polymorphisms implicated in schizophrenia included in this review

From: An actualized screening of schizophrenia-associated genes

References

Ethnicity

Total sample

No. of case/control

Mean age (case/control)

% Men (case/control)

Genotyping method

Gene

Polymorphism

Associated/no associated

Mazaheri and Saadat [29]

Iranian

726

363/363

41.4±13.1/39.7±11.1

73.8%/73.8%

PCR Assay

ACE

I/D

Yes (insertion with women)

Ozsoy et al. [32]

Turkish

252

100/152

39.11 ± 10.08/47.74 ± 13.26

55%/60.5%

PCR–RFLP

AUTS2

rs6943555

Yes

Zhang et al. [37]

Chinese Han

2240

1086/1154

34.24 ± 12.26/

/

Mass ARRAY/

C3

rs11569562

Yes (rs11569514)

    

36.47 ± 10.93

 

PCR

I

rs344555

 
       

I

rs2241393

 
   

I

   

rs11569514

  
       

I

rs445750

 

Fu et al. [16]

Chinese Han

1536

761/775

34.61 ± 12.02/

58.2%/56.2%

MALDI-TOF–MS technology

CACNA2D2

rs12496815

Yes (rs45536634)

    

34.74 ± 11.41

  

I

rs3806706

 
       

I

rs45536634

 

Chu et al. [12]

Taiwan

515

248/267

39.22 ± 10.64/

56%/81.6%

SNPlex genotyping system

DAO

rs3741775

No

    

36.13 ± 11.95

     

Chu et al. [12]

Taiwan

515

248/267

39.22 ± 10.64/

56%/81.6%

SNPlex genotyping system

DAOA

rs3916956

Yes (rs778292, rs3918342, rs1421292)

    

36.13 ± 11.95

  

I

rs2391191

 
       

I

rs778292

 
       

I

rs3918342

 
       

I

rs1421292

 

Fatima et al. [15]

Pakistani

300

150/150

34.07 ± 9.5/

65.3%/61.3%

PCR/PCR–RFLP

DISC

rs1417584

Yes (rs1417584)

    

33.8 ± 10.6

  

I

rs1954175

 
       

I

rs821616

 
       

I

rs113012343

 

He et al. [18]

Chinese

484

248/236

54.39 ± 13.39/

64.5%/65.6%

MassARRAY

DISC1

rs821616

Yes (rs821616,

    

56.11 ± 12.91

  

I

rs821597

rs821597)

Zhang et al. [39]

Northeast Chinese Han

630

306/324

44.6 ± 7.3/

50.3%/48.5%

PCR

DRD2

rs7116768

No

    

45.3 ± 15.9

  

I

rs1799732

 

Pae et al. [33]

Korean

1509

908/601

38.9 /33.7

50.5%/50.9%

Pyrosequencer

DTNBP1

rs3213207

Yes (rs760761, rs2619522)

       

I

rs1011313

 
       

I

rs760761

 
       

I

rs2619522

 

Gao et al. [28]

Northern Chinese

602

281/321

41.1 ± 7.1/

50.8%/48.2%

PCR

EFHD2

rs2473357

Yes (rs2473357)

 

Han

  

43.7 ± 7.4

  

I

rs71631726

 
       

I

rs140124965

 
       

I

rs10927785

 

Al-Eitan et al. [7]

Jordan

380

185/195

45 .9 ± 12.6/

100%/100%

PCR

ERBB4

rs839523 (G/A)

Yes (rs839523)

    

31.4 ± 8.1

  

I

rs3748962 (A/G)

 

Heidari Nia et al. [19]

Iranian

390

190/200

36.48 ±10.52/36.40±10.88

/

Tetra-ARMS-PCR

GABRB2

rs12187676(G/C)

Yes (rs1816072)

       

I

rs1816072 (T/C)

 

Yang et al. [40]

Chinese

1504

893/611

50.4 ± 13.4/

56.4%/54.5%

PCR

GLRX5

rs1007814

Yes (rs1007814)

    

42.0 ± 9.9

     

Kang et al. [23]

Korean

598

218/380

42.2 ± 10.6/

/

PCR

GRIA1

rs1428920

Yes (rs1428920,

    

44.3 ± 6.3

  

I

rs1552834

rs2926835)

       

I

rs1422889

 
       

I

rs10035143

 
       

I

rs2926835

 

Ren et al. [36]

Chinese

2068

1034/1034

45.06 ± 12.88/

60.4%/56.8%

MassARRAY

GRIK4 rs79526501

No

 
    

34.06 ± 10.0

 

Sequenom

I

rs4582985

 
       

I

rs11218016

 
       

I

rs6589847

 
       

I

rs56275759

 

Norton et al. [31]

European & American

1390

674/716

44.5 ± 14.6/

71.5%/63.6%

Sequenom

GRM3

rs187993

No

    

41.5 ± 11.5

 

MassARRAY

I

rs13242038

 
      

PCR

I

rs917071

 
       

I

rs6465084

 
       

I

rs2228595

 
       

I

rs1468412

 
       

I

rs3804100

 

Raffa et al. [35]

Tunisian

261

138/123

32.67 ± 7.44/

86.9%/80.4%

PCR

GSTs

GSTM1

Yes (GSTT1)

    

31.28 ± 5.28

  

I

GSTT1

 

Kim et al. [25]

Korean

512

278/234

42.91 ± 10.91/

67.9%/41%

SeqMan II software

HDAC

HDAC3 (rs2530223)

Yes (HDAC3, HDAC4)

    

36.06 ± 6.08

  

I

HDAC4 (rs1063639)

 
       

I

HDAC10 (rs155048)

 

Kowalczyk et al. [26]

Polish

1080

401/679

41.3 ± 12.4/

59.6%/52.8%

PCR–RFLP

HSPA1A

rs1008438

No

    

40.4 ± 8.7

 

TaqMan

I

rs562047

 

Kowalczyk et al. [27]

Polish

901

377/524

41.1 ± 12.3/

59.4%/55.34

PCR–RFLP/TaqMan Assays

HSPA1B

rs6457452

No

    

39.8 ± 9.1

  

I

rs2763979

 
       

I

rs539689

 
       

I

rs9281590

 

Kowalczyk et al. [26]

Polish

1080

401/679

41.3 ± 12.4/

59.6%/52.8%

PCR–RFLP

HSPA1L

rs2075800

No

    

40.4 ± 8.7

 

TaqMan

   

Jemli et al. [21]

Tunisian

391

225/166

39.7 ± 10.02/

77.7%/61.4%

PCR–RFLP

IFNGR2

Q64R(Gln64Arg)

Yes (Men)

    

28.37 ± 8.44

     

Philibert et al. [34]

European, African-American, Hispanic, Asian

565

206/359

39.8 ± 10.8/

63.5%/50.6%

Flurescent Primer

MTHFR

C677T

No

      

Probe

   

Harada et al. [17]

Japanese

336

102/234

46.9 ± 14.2/

59.8%/70.1%

PCR

NQO2

I/D

Yes (Deletion)

    

46.4 ± 9.1

     

He et al. [18]

Chinese

484

248/236

54.39 ± 13.39/

64.5%/65.6%

MassARRAY

NRG1 rs3924999

Yes (rs3924999)

 
    

56.11 ± 12.91

     

Yue et al. [42]

Chinese Han

1506

768/738

33.5 ± 8.7/

46.8%/48.5%

TaqMan

NRXN1

rs10490168

Yes (rs10490168, rs2024513, rs13382584,

    

32.2 ± 6.4

  

I

rs2024513

rs1558852)

       

I

rs10174398

 
       

I

rs10195460

 
       

I

rs13382584

 
       

I

rs1558852

 

Ding et al. [13]

Chinese Han

528

264/264

37.44 ± 11.04/

58.3%/55.3%

PCR–RFLP

OPRM1

rs1799971

Yes (rs1799971

    

36.38 ± 12.27

  

I

rs2075572

rs2075572)

       

I

rs648893

 
       

I

rs671531

 

Yenilmez et al. [41]

Turkish

250

150/100

/

/

PCR

PAI-1

4G/5G (I/D)

No

Fatemi et al. [14]

Caucasian, African

1482

878/604

/

/

TaqMan

PDE4B

rs1354064

Yes (rs1354064,

 

American

     

I

rs4320761

rs4320761, rs1040716, rs910694, rs1321177, rs2144719, rs783038, rs599381

       

I

rs1040716

 
       

I

rs910694

 
       

I

rs1321177

 
       

I

rs2144719

 
       

I

rs783038

 
       

I

rs599381

 

Nadalin et al. [30]

Croatian

394

203/191

40.1 ± 8.8/

54.6%/45.5%

PCR–RFLP

PPARα

L162V

No

Bae et al. [9]

Korean

842

449/393

44.92/54.62

55.7%/56.5%

TaqMan Assay

RANBP9

rs24023

No

       

I

rs442458

 
       

I

rs6940759

 
       

I

rs204226

 
       

I

rs11759518

 
       

I

Ins/Supp(rs16724)

 

Bai et al. [10]

Northeast Chinese Han

1536

761/775

34.61 ± 12.02/

58.2%/56.1

Mass ARRAY

RELN

rs1062831

Yes (rs362746)

    

34.74 ± 11.41

  

I

rs3808039

 
       

I

rs362746

 
       

I

rs736707

 

Bermudo-Soriano et al. [11]

Spanish

593

180/413

41.95/38.85

53.8%/38%

PCR

SAT-1

-1415 T/C SNP

No

Gao et al. [20]

Chinese

1076

448/628

36.1 ± 10.2/

49.5%/42.9

PCR/SNPscan

TCF4

rs1261085

Yes (rs2958182)

    

35.7 ± 9.7

  

I

rs1261084

 
       

I

rs8766

 
       

I

rs9960767

 
       

I

rs2958182

 
       

I

rs12966547

 

Kang et al. [24]

Korean

591

286/305

42.8 ± 10.8/

66.7%/48.1%

PCR

TLR2

rs3804099 (Asn199Asn)

Yes (rs380499,

    

36.6/6.8

  

I

rs3804100 (Ser450Ser)

Rs3804100)

Gao et al. [22]

Chinese Han

1986

1034/952

49.44 ± 17.95/

64.7%/51.2%

TaqMan

VEGFA

rs699947

No

    

34.45 ± 10.12

  

I

rs25648

 
       

I

rs833070

 
       

I. rs3024997

rs3024997

 
       

I

rs10434

 

Zhang et al. [8]

Northwest

893

360/533

37.2 ± 10.4/

49.1%/43.5%

PCR

VRK2

rs2312147

Yes (rs3732136)

 

Chinese Han

  

35.6 ± 11.2

  

I

rs1051061

 
       

I

rs2043890

 
       

I

rs3732136

 

Taghipour et al. [38]

Iran

721

361/360

41.9 ± 13.5/40.6 ± 13.2/

72.3%/74.1

SNP Alyze (TM) software

XPC

Ala499Val

Yes (Haplotype Val-Lys)

       

I

PAT

 
       

I

Lys939Gln

Â