Association of gene polymorphisms of ACE, AGT, and ARNT-like protein 1 with susceptibility to gestational diabetes

Ashour, Esmat; Gouda, Weaam; Mageed, Lamiaa; Okasha, Ahmed; Afify, Mie; Fawzi, Olfat M.

doi:10.1186/s43042-022-00273-1

Egyptian Journal of Medical Human Genetics

Table 6 Haplotype association of ACE (I/D), AGT (M/T), and ARNT (G/A) between GDM and control groups

From: Association of gene polymorphisms of ACE, AGT, and ARNT-like protein 1 with susceptibility to gestational diabetes

Haplotype	Group		Chi-square (X²)	P value	Risk
Haplotype	GDM	Control	Chi-square (X²)	P value	OR	95% CI
II + MM + GG	0 (0.0%)	50 (100.0%)	32.879	0.001*	2.400	1.229–4.688
II + MM + AA	4 (100.0%)	0 (0.0%)	2.424	0.119	1.714	1.063–2.765
II + MT + GG	0 (0.0%)	10 (100.0%)	8.556	0.003*	2.400	1.229–4.688
II + MT + GA	0 (0.0%)	10 (100.0%)	8.556	0.003*	2.400	1.229–4.688
II + TT + GG	0 (0.0%)	5 (100.0%)	4.958	0.026*	2.400	1.229–4.688
II + TT + GA	3 (100.0%)	0 (0.0%)	1.875	0.171	1.714	1.063–2.765
II + TT + AA	1 (16.7%)	5 (83.3%)	2.812	0.094	0.143	0.013–1.630
ID + MM + GG	1 (6.2%)	15 (93.8%)	9.115	0.003*	0.048	0.005–0.488
ID + MM + GA	8 (28.6%)	20 (71.4%)	3.175	0.075	0.286	0.070–1.171
ID + MM + AA	3 (37.5%)	5 (62.5%)	0.833	0.361	0.429	0.068–2.684
ID + MT + GG	7 (58.3%)	5 (41.7%)	0.001	1.000	1.000	0.197–5.068
ID + MT + GA	24 (82.8%)	5 (17.2%)	2.746	0.098	3.429	0.766–15.342
ID + MT + AA	13 (100.0%)	0 (0.0%)	6.771	0.009*	1.714	1.063–2.765
ID + TT + GG	1 (100.0%)	0 (0.0%)	0.677	0.411	1.714	1.063–2.765
ID + TT + GA	5 (100.0%)	0 (0.0%)	2.951	0.086	1.714	1.063–2.765
ID + TT + AA	6 (100.0%)	0 (0.0%)	3.462	0.063	1.714	1.063–2.765
DD + MM + GA	4 (16.7%)	20 (83.3%)	6.545	0.011*	0.143	0.030–0.688
DD + MM + AA	0 (0.0%)	5 (100.0%)	4.958	0.026*	2.400	1.229–4.688
DD + MT + GG	11 (100.0%)	0 (0.0%)	5.856	0.016*	1.714	1.063–2.765
DD + MT + GA	9 (100.0%)	0 (0.0%)	4.922	0.027*	1.714	1.063–2.765
DD + MT + AA	28 (100.0%)	0 (0.0%)	13.333	0.001*	1.714	1.063–2.765
DD + TT + GG	10 (66.7%)	5 (33.3%)	0.199	0.656	1.429	0.297–6.877
DD + TT + GA	15 (100.0%)	0 (0.0%)	7.670	0.006*	1.714	1.063–2.765
DD + TT + AA	7 (58.3%)	5 (41.7%)	Reference

Data are presented as number (percentage %). X²: chi-square statistic
95% CI: 95% confidence intervals. OR: odds ratio
Bold values indicate significant difference. *P value ≤ 0.05 was considered significant

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