The role of tumor necrosis factor alpha − 308A > G polymorphism on the clinical states of SARS-CoV-2 infection

Sotomayor-Lugo, Francisco; Alemañy-Díaz Perera, Claudia; Roblejo-Balbuena, Hilda; Zúñiga-Rosales, Yaíma; Monzón-Benítez, Giselle; Suárez-Besil, Beatriz; González-Torres, María de los Ángeles; Torres-Rives, Bárbara; Álvarez-Gavilán, Yudelmis; Bravo-Ramírez, Maidalys; Pereira-Roche, Nayade; Benítez-Cordero, Yudelkis; Silva-Ayçaguer, Luis Carlos; Marcheco-Teruel, Beatriz

doi:10.1186/s43042-022-00274-0

Egyptian Journal of Medical Human Genetics

Table 2 Genotype and allele frequencies of TNFα − 308A > G polymorphism by province in Cuba

From: The role of tumor necrosis factor alpha − 308A > G polymorphism on the clinical states of SARS-CoV-2 infection

Location		Reference group frequencies	Study group frequencies	Location		Reference group frequencies	Study group frequencies	Location		Reference group frequencies	Study group frequencies
Cuba		n = 948	n = 1028	Matanzas		n = 68	n = 116	Las Tunas		n = 43	n = 13
Genotype	GG	76.7	79.7	Genotype	GG	73.5	82.7	Genotype	GG	81.4	84.6
	AG	21.7	18.4		AG	25.0	14.7		AG	18.6	15.4
	AA	1.6	1.9		AA	1.5	2.6		AA	0	0.0
Allele	G	0.88	0.89	Allele	G	0.86	0.90	Allele	G	0.91	0.92
	A	0.12	0.11		A	0.14	0.10		A	0.09	0.08
Isle of Youth		n = 2	n = 34	Villa Clara		n = 101	n = 133	Holguín		n = 116	n = 54
Genotype	GG	50.0	76.5	Genotype	GG	79.2	78.2	Genotype	GG	73.3	88.9^a
	AG	50.0	23.5		AG	19.8	20.3		AG	25.0	11.1^a
	AA	0.0	0.0		AA	1.0	1.5		AA	1.7	0.0
Allele	G	0.75	0.88	Allele	G	0.89	0.88	Allele	G	0.86	0.94
	A	0.25	0.12		A	0.11	0.12		A	0.14	0.06
Pinar del Río		n = 79	n = 36	Cienfuegos		n = 29	n = 18	Granma		n = 88	n = 8
Genotype	GG	75.9	88.9	Genotype	GG	72.4	77.8	Genotype	GG	84.1	100.0
	AG	19.0	11.1		AG	27.6	22.2		AG	14.8	0.0
	AA	5.1	0.0		AA	0	0.0		AA	1.1	0.0
Allele	G	0.85	0.94	Allele	G	0.86	0.89	Allele	G	0.91	1.00
	A	0.15	0.06		A	0.14	0.11		A	0.09	0.00
Artemisa		n = 29	n = 22	Sancti Spíritus		n = 58	n = 54	Santiago de Cuba		n = 98	n = 32
Genotype	GG	72.4	72.7	Genotype	GG	70.7	74.1	Genotype	GG	74.5	84.4
	AG	27.6	27.3		AG	29.3	24.1		AG	23.5	12.5
	AA	0.0	0.0		AA	0	1.8		AA	2.0	3.1
Allele	G	0.86	0.86	Allele	G	0.85	0.86	Allele	G	0.86	0.91
	A	0.14	0.14		A	0.15	0.14		A	0.14	0.09
Mayabeque		n = 28	n = 27	Ciego de Ávila		n = 34	n = 74	Guantánamo		n = 57	n = 13
Genotype	GG	85.7	74.1	Genotype	GG	70.6	71.6	Genotype	GG	78.9	84.6
	AG	14.3	25.9		AG	29.4	24.3		AG	21.1	7.7
	AA	0	0.0		AA	0	4.05		AA	0	7.7
Allele	G	0.93	0.87	Allele	G	0.85	0.84	Allele	G	0.89	0.88
	A	0.07	0.13		A	0.15	0.16		A	0.11	0.12
Havana		n = 74	n = 363	Camagüey		n = 44	n = 31
Genotype	GG	73.0	79.6	Genotype	GG	88.6	77.4
	AG	23.0	18.2		AG	9.1	19.4
	AA	4.0	2.2		AA	2.3	3.2
Allele	G	0.84	0.89	Allele	G	0.93	0.87
	A	0.16	0.11		A	0.07	0.13

Frequencies of TNFa − 308 genotypes are presented in percentages, and allele frequencies are showed in proportions
n number of subjects
^aDifferences by the z test

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