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Table 3 Genotype frequencies and odds ratios in degree of severity and clinical forms of COVID-19 according to TNFα − 308A > G polymorphism genotypes

From: The role of tumor necrosis factor alpha − 308A > G polymorphism on the clinical states of SARS-CoV-2 infection

Characteristics

Genotypes

GG (%)

OR (95% CI)

AG (%)

OR (95% CI)

AA (%)

OR (95% CI)

Severity of symptomatic forms of COVID-19

 MS (n = 551)

430 (78.0)

0.81 (0.59–1.09)

110 (20.0)

1.26 (0.91–1.73)

11 (2.0)

1.06 (0.44–2.58)

 SS (n = 66)

53 (80.3)

1.04 (0.56–1.95)

12 (18.2)

0.99 (0.52–1.88)

1 (1.5)

0.76 (0.10–5.79)

Clinical forms

 MS&SS (617)

483 (78.3)

0.81 (0.59–1.10)

122 (19.8)

1.27 (0.91–1.76)

12 (1.9)

0.99 (0.41–2.47)

 AS (n = 411)

336 (81.8)a

1.24 (0.91–1.70)

67 (16.3)a

0.79 (0.57–1.10)

8 (1.9)

1.00 (0.41–2.47)

  1. Frequencies of TNFa − 308 genotypes are presented in absolute values and percentages
  2. AS asymptomatic, MS mild symptomatic, SS severe symptomatic
  3. aDifferences by the z test when compared with the Cuban reference population