Table 1 Genotype frequencies of MTHFR (rs1801133)gene mutation in the studied subjects
Patients group | Genotype | Patients n (%) | Control n (%) | ORa (95%C.I) | P value |
|---|---|---|---|---|---|
Azoospermic n = 90 | CC | 41(45.5) | 70(70) | 1 |  |
CT | 30(33.3) | 25(25) | 2.0(1.1–3.9) | 0.03 | |
TT | 19(21.1) | 5(5) | 4.5(2.3–10.7) | 0.0005 | |
CT + TT | 49(54.4) | 30(30) | 2.8(1.5–5) | 0.0007 | |
Oligospermic n = 84 | CC | 42(50) | 70(70) | 1 |  |
CT | 25(29.7) | 25(25) | 1.7(0.8–3.3) | 0.1 | |
TT | 17(20.2) | 5(5) | 3.7(1.9–6.6) | 0.002 | |
CT + TT | 42(50) | 30(30) | 2.3(1.2–4.2) | 0.006 | |
Asthenospermic n = 64 | CC | 31(48.9) | 70(70) | 1 |  |
CT | 24(37.5) | 25(25) | 2.2(1.0–4.4) | 0.03 | |
TT | 9(14) | 5(5) | 4.0(1.2–7.1) | 0.01 | |
CT + TT | 33(51.5) | 30(30) | 2.5(1.3–4.8) | 0.006 | |
OligoAsthenospermic n = 50 | CC | 22(44) | 70(70) | 1 |  |
CT | 18(36) | 25(25) | 2.8(1.0–4.9) | 0.03 | |
TT | 10(20) | 5(5) | 6.3(1.9–9.2) | 0.002 | |
CT + TT | 28(56) | 30(30) | 2.9(1.4–6.0) | 0.002 | |
Teratospermic n = 65 | CC | 31(47.7) | 70(70) | 1 |  |
CT | 19(29) | 25(25) | 1.7(0.8–3.5) | 0.1 | |
TT | 15(23.1) | 5(5) | 5.0(2.2–9.8) | 0.0006 | |
CT + TT | 49(75) | 30(30) | 3.0(1.6–4.8) | 0.0001 | |
Total infertile subjects | CC | 167(47.3) | 70(70) | 1 | Â |
CT | 116(32.9) | 25(25) | 2.0(1.2–3.3) | 0.011 | |
TT | 70(21.1) | 5(5) | 4.8(2.3–8.2) | 0.0003 | |
CT + TT | 201(56.9) | 30(30) | 2.8(1.7–4.5) | 0.0001 |