Problem of borderline hemoglobin A2 levels in an Iranian population with a high prevalence of α- and β-thalassemia carriers

Moradi, Keivan; Alibakhshi, Reza; Shafieenia, Samaneh; Azimi, Azam

doi:10.1186/s43042-022-00279-9

Egyptian Journal of Medical Human Genetics

Table 2 Couples with α- or β-thal genotypes at risk for having a child with thalassemia

From: Problem of borderline hemoglobin A₂ levels in an Iranian population with a high prevalence of α- and β-thalassemia carriers

Gender	Hb A₂	Genotype	Gender	Hb A₂	Genotype	Gender	Hb A₂	Genotype
α-Thalassemia genotypes
Male	3.5	αα/–^{MED I}	Male	2.3	αα/α^PolyA1α	Male^a	3.1	αα/αα^{Hb Adana}
Female	2.7	αα/–^{MED I}	Female	3.2	αα/-α^3.7	Female^a	2.8	αα/αα^{Hb Adana}
Male^a	2.4	αα/αα^{Hb Adana}	Male^a	3.0	αα/αα^{Hb Adana}	Male	3.1	αα/α^PolyA1α
Female^a	3.2	αα/αα^{Hb Adana}	Female^a	3.5	αα/αα^{Hb Adana}	Female	2.2	-α^3.7/-α^3.7
Male^a	3.3	αα/α^PolyA2α	Male	2.1	αα/–^{MED I}
Female^a	2.8	αα/α^PolyA2α	Female	3.2	αα/α^−5ntα
β-Thalassemia genotypes
Male^a	4.8	Codons 8/9 (+G)/W	Male^a	3.6	IVS-II-1 (G>A)/ W	Male^a	3.9	IVS-II-1 (G>A)/ W
Female^a	3.4	Codons 8/9 (+ G)/ W	Female^a	5.0	IVS-II-1 (G > A)/ W	Female^a	4.1	IVS-II-1 (G > A)/ W
Male^a	2.8	IVS-I-6 (T>C)/ W	Male^a	3.7	Codons 8/9 (+G)/ W	Male	3.7	IVS-I-110 (G>A)/ W
Female^a	3.2	IVS-I-6 (T>C)/ W	Female^a	4.4	Codons 8/9 (+G)/ W	Female	4.1	IVS-I-110 (G>A)/ W
Male^a	3.7	IVS-I-6 (T>C)/W	Male^a	4.5	IVS-II-1 (G>A)/ W	Male^a	2.7	IVS-I-6 (T>C)/ W
Female^a	5.9	Codon 39 (C>T)/ W	Female^a	3.7	IVS-II-1 (G>A)/ W	Female^a	3.9	IVS-I-6 (T>C)/ W
Male^a	3.9	IVS-I-6 (T>C)/ W	Male	3.7	IVS-II-1 (G>A)/ W	Male^a	3.9	IVS-II-1 (G>A)/ W
Female^a	3.9	IVS-I-6 (T>C)/ W	Female	4.4	Codons 82/83 (–G)/ W	Female^a	4.6	IVS-II-1 (G>A)/ W
Male	3.8	IVS-II-1 (G>A)/ W	Male^a	3.7	IVS-I-110 (G>A)/ W	Male^a	4.6	IVS-II-1 (G>A)/ W
Female	3.9	IVS-II-1 (G>A)/ W	Female^a	4.5	IVS-II-1 (G>A)/ W	Female^a	3.9	IVS-II-1 (G>A)/ W
Male^a	3.7	IVS-I-6 (T>C)/ W	Male^a	3.8	Codons 8/9 (+G)/ W	Male^a	4.3	IVS-I-1 (G>A)/ W
Female^a	4.2	IVS-I-6 (T>C)/ W	Female^a	3.7	Codons 8/9 (+G)/ W	Female^a	3.9	IVS-I-1 (G>A)/ W
Male^a	4.2	Codon 44 (–C)/ W	Male^a	3.6	IVS-I-128 (T>G)/ W	Male	3.8	IVS-I-6 (T>C)/ W
Female^a	3.9	Codon 44 (–C)/ W	Female^a	3.6	IVS-I-128 (T>G)/ W	Female	6.2	Codon 39 (C>T)/ W
Male^a	3.9	Codons 25/26 (+T)/ W	Male	5.0	IVS-II-1 (G>A)/ W	Male	3.8	IVS-I-6 (T>C)/ W
Female^a	4.6	Codons 25/26 (+T)/ W	Female	3.7	IVS-I-6 (T>C)/ W	Female	5.2	IVS-II-1 (G>A)/ W
Male^a	4.3	IVS-II-1 (G>A)/ W	Male^a	3.5	IVS-I-6 (T>C)/ W	Male^a	3.9	IVS-I-6 (T>C)/ W
Female^a	3.6	IVS-II-1 (G>A)/ W	Female^a	3.9	IVS-II-1 (G>A)/ W	Female^a	3.9	IVS-I-6 (T>C)/ W
Male	3.8	IVS-I-6 (T>C)/ W	Male	4.4	IVS-II-1 (G>A)/ W	Male^a	3.9	IVS-I-6 (T>C)/ W
Female	4.6	Codons 8/9 (+G)/ W	Female	3.8	Codons 36/37 (–T)/ W	Female^a	3.9	IVS-I-6 (T>C)/ W
Male	4.1	IVS-I-110 (G>A)/ W	Male^a	3.8	IVS-I-6 (T>C)/ W	Male^a	4.5	IVS-II-1 (G>A)/ W
Female	3.6	IVS-I-110 (G>A)/ W	Female^a	2.7	IVS-I-6 (T>C)/ W	Female^a	3.8	IVS-II-1 (G>A)/ W
Male	3.8	Codons 82/83 (–G)/ W	Male^a	5.3	IVS-II-1 (G>A)/ W	Male^a	3.9	IVS-II-1 (G>A)/ W
Female	4.4	Codons 82/83 (–G)/ W	Female^a	3.5	–101 (C>T)/ W	Female^a	4.0	IVS-II-1 (G>A)/ W
Male	6.0	Codons 8/9 (+G)/ W	Male^a	4.5	Codon 15 (G>A)/ W	Male^a	4.7	Codon 22 (G>T)/ W
Female	3.8	Codons 8/9 (+G)/ W	Female^a	3.7	Codon 15 (G>A)/ W	Female^a	3.9	Codon 22 (G>T)/ W
Male	4.0	IVS-I (25 bp del.)/ W	Male^a	5.0	IVS-I-110 (G>A)/ W	Male	3.9	–101 (C>T)/ W
Female	3.9	IVS-I-1 (G>A)/ W	Female^a	3.5	IVS-I-128 (T>G)/ W	Female	5.5	–101 (C>T)/ W
Male	3.7	–101 (C>T)/ W	Male	3.9	–101 (C>T)/ W	Male^b	4.5	Codons 82/83 (–G)/ W
Female	5.6	IVS-I-6 (T>C)/ W	Female	5.0	Codon 44 (–C)/ W	Female^b	3.9	Codons 8/9 (+G)/ W
Male^a,b	3.9	IVS-I-6 (T>C)/ W	Male^a,b	3.9	IVS-II-1 (G>A)/ W	Male^b	3.9	–101 (C>T)/ W
Female^a,b	4.5	IVS-I-6 (T>C)/ W	Female^a,b	6.2	IVS-II-1 (G>A)/ W	Female^b	5.0	Codon 44 (–C)/ W
Male^a,b	3.8	Cap+22 (G>A)/ W	Male^a,b	4.9	Codon 5 (–CT)/ W	Male^b	3.7	IVS-I-6 (T>C)/ W
Female^a,b	3.7	Cap+22 (G>A)/ W	Female^a,b	3.7	IVS-I-6 (T>C)/ W	Female^b	5.7	Codons 8/9 (+G)/ W

Codon 39 (C >T) (HBB: c.118C>T); Codon 44 (–C) (HBB: c.135delC); Codons 25/26 (+T) (HBB: c.78_79insT); Codon 15 (G>A) (HBB: c.48G>A); Codon 22 (G>T) (HBB: c.67G>T); IVS-I (25bp del) (HBB: c.93-21_del); Cap+22 (G>A) (HBB: c.-29G>A); Codon 5 (–CT) (HBB: c.17_18delCT)
^aConsanguineous couples
^bCouples who had a child with thalassemia

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