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Table 2 Couples with α- or β-thal genotypes at risk for having a child with thalassemia

From: Problem of borderline hemoglobin A2 levels in an Iranian population with a high prevalence of α- and β-thalassemia carriers

Gender Hb A2 Genotype Gender Hb A2 Genotype Gender Hb A2 Genotype
α-Thalassemia genotypes
 Male 3.5 αα/–MED I Male 2.3 αα/αPolyA1α Malea 3.1 αα/ααHb Adana
 Female 2.7 αα/–MED I Female 3.2 αα/-α3.7 Femalea 2.8 αα/ααHb Adana
 Malea 2.4 αα/ααHb Adana Malea 3.0 αα/ααHb Adana Male 3.1 αα/αPolyA1α
 Femalea 3.2 αα/ααHb Adana Femalea 3.5 αα/ααHb Adana Female 2.2 3.7/-α3.7
 Malea 3.3 αα/αPolyA2α Male 2.1 αα/–MED I    
 Femalea 2.8 αα/αPolyA2α Female 3.2 αα/α−5ntα    
β-Thalassemia genotypes
 Malea 4.8 Codons 8/9 (+G)/W Malea 3.6 IVS-II-1 (G>A)/ W Malea 3.9 IVS-II-1 (G>A)/ W
 Femalea 3.4 Codons 8/9 (+ G)/ W Femalea 5.0 IVS-II-1 (G > A)/ W Femalea 4.1 IVS-II-1 (G > A)/ W
 Malea 2.8 IVS-I-6 (T>C)/ W Malea 3.7 Codons 8/9 (+G)/ W Male 3.7 IVS-I-110 (G>A)/ W
 Femalea 3.2 IVS-I-6 (T>C)/ W Femalea 4.4 Codons 8/9 (+G)/ W Female 4.1 IVS-I-110 (G>A)/ W
 Malea 3.7 IVS-I-6 (T>C)/W Malea 4.5 IVS-II-1 (G>A)/ W Malea 2.7 IVS-I-6 (T>C)/ W
 Femalea 5.9 Codon 39 (C>T)/ W Femalea 3.7 IVS-II-1 (G>A)/ W Femalea 3.9 IVS-I-6 (T>C)/ W
 Malea 3.9 IVS-I-6 (T>C)/ W Male 3.7 IVS-II-1 (G>A)/ W Malea 3.9 IVS-II-1 (G>A)/ W
 Femalea 3.9 IVS-I-6 (T>C)/ W Female 4.4 Codons 82/83 (–G)/ W Femalea 4.6 IVS-II-1 (G>A)/ W
 Male 3.8 IVS-II-1 (G>A)/ W Malea 3.7 IVS-I-110 (G>A)/ W Malea 4.6 IVS-II-1 (G>A)/ W
 Female 3.9 IVS-II-1 (G>A)/ W Femalea 4.5 IVS-II-1 (G>A)/ W Femalea 3.9 IVS-II-1 (G>A)/ W
 Malea 3.7 IVS-I-6 (T>C)/ W Malea 3.8 Codons 8/9 (+G)/ W Malea 4.3 IVS-I-1 (G>A)/ W
 Femalea 4.2 IVS-I-6 (T>C)/ W Femalea 3.7 Codons 8/9 (+G)/ W Femalea 3.9 IVS-I-1 (G>A)/ W
 Malea 4.2 Codon 44 (–C)/ W Malea 3.6 IVS-I-128 (T>G)/ W Male 3.8 IVS-I-6 (T>C)/ W
 Femalea 3.9 Codon 44 (–C)/ W Femalea 3.6 IVS-I-128 (T>G)/ W Female 6.2 Codon 39 (C>T)/ W
 Malea 3.9 Codons 25/26 (+T)/ W Male 5.0 IVS-II-1 (G>A)/ W Male 3.8 IVS-I-6 (T>C)/ W
 Femalea 4.6 Codons 25/26 (+T)/ W Female 3.7 IVS-I-6 (T>C)/ W Female 5.2 IVS-II-1 (G>A)/ W
 Malea 4.3 IVS-II-1 (G>A)/ W Malea 3.5 IVS-I-6 (T>C)/ W Malea 3.9 IVS-I-6 (T>C)/ W
 Femalea 3.6 IVS-II-1 (G>A)/ W Femalea 3.9 IVS-II-1 (G>A)/ W Femalea 3.9 IVS-I-6 (T>C)/ W
 Male 3.8 IVS-I-6 (T>C)/ W Male 4.4 IVS-II-1 (G>A)/ W Malea 3.9 IVS-I-6 (T>C)/ W
 Female 4.6 Codons 8/9 (+G)/ W Female 3.8 Codons 36/37 (–T)/ W Femalea 3.9 IVS-I-6 (T>C)/ W
 Male 4.1 IVS-I-110 (G>A)/ W Malea 3.8 IVS-I-6 (T>C)/ W Malea 4.5 IVS-II-1 (G>A)/ W
 Female 3.6 IVS-I-110 (G>A)/ W Femalea 2.7 IVS-I-6 (T>C)/ W Femalea 3.8 IVS-II-1 (G>A)/ W
 Male 3.8 Codons 82/83 (–G)/ W Malea 5.3 IVS-II-1 (G>A)/ W Malea 3.9 IVS-II-1 (G>A)/ W
 Female 4.4 Codons 82/83 (–G)/ W Femalea 3.5 –101 (C>T)/ W Femalea 4.0 IVS-II-1 (G>A)/ W
 Male 6.0 Codons 8/9 (+G)/ W Malea 4.5 Codon 15 (G>A)/ W Malea 4.7 Codon 22 (G>T)/ W
 Female 3.8 Codons 8/9 (+G)/ W Femalea 3.7 Codon 15 (G>A)/ W Femalea 3.9 Codon 22 (G>T)/ W
 Male 4.0 IVS-I (25 bp del.)/ W Malea 5.0 IVS-I-110 (G>A)/ W Male 3.9 –101 (C>T)/ W
 Female 3.9 IVS-I-1 (G>A)/ W Femalea 3.5 IVS-I-128 (T>G)/ W Female 5.5 –101 (C>T)/ W
 Male 3.7 –101 (C>T)/ W Male 3.9 –101 (C>T)/ W Maleb 4.5 Codons 82/83 (–G)/ W
 Female 5.6 IVS-I-6 (T>C)/ W Female 5.0 Codon 44 (–C)/ W Femaleb 3.9 Codons 8/9 (+G)/ W
 Malea,b 3.9 IVS-I-6 (T>C)/ W Malea,b 3.9 IVS-II-1 (G>A)/ W Maleb 3.9 –101 (C>T)/ W
 Femalea,b 4.5 IVS-I-6 (T>C)/ W Femalea,b 6.2 IVS-II-1 (G>A)/ W Femaleb 5.0 Codon 44 (–C)/ W
 Malea,b 3.8 Cap+22 (G>A)/ W Malea,b 4.9 Codon 5 (–CT)/ W Maleb 3.7 IVS-I-6 (T>C)/ W
 Femalea,b 3.7 Cap+22 (G>A)/ W Femalea,b 3.7 IVS-I-6 (T>C)/ W Femaleb 5.7 Codons 8/9 (+G)/ W
  1. Codon 39 (C >T) (HBB: c.118C>T); Codon 44 (–C) (HBB: c.135delC); Codons 25/26 (+T) (HBB: c.78_79insT); Codon 15 (G>A) (HBB: c.48G>A); Codon 22 (G>T) (HBB: c.67G>T); IVS-I (25bp del) (HBB: c.93-21_del); Cap+22 (G>A) (HBB: c.-29G>A); Codon 5 (–CT) (HBB: c.17_18delCT)
  2. aConsanguineous couples
  3. bCouples who had a child with thalassemia