Problem of borderline hemoglobin A2 levels in an Iranian population with a high prevalence of α- and β-thalassemia carriers

Egyptian Journal of Medical Human Genetics

Table 4 Comparison of mean values of Hb A₂, MCV and MCH in α-thalassemia genotypes (as a single group) with those in common β-thalassemia genotypes identified in this study

Genotype	n	Hb A₂			MCV			MCH
Genotype	n	Min; max	Mean	p value	Min; max	Mean	p value	Min; max	Mean	p value
α-Thalassemia genotypes	127	3.1; 3.9	3.23 ± 0.18		59.9; 102.5	75.87 ± 5.69		18.3; 32.5	24.22 ± 2.31
IVS-II-1 (G>A)/ W	36	3.1; 3.9	3.70 ± 0.23	< 0.0001	58.6; 76.4	64.73 ± 4.40	< 0.0001	17.0; 24.7	19.86 ± 1.70	< 0.0001
IVS-I-6 (T>C)/ W	30	3.1; 3.9	3.71 ± 0.22	< 0.0001	63.0; 78.2	69.28 ± 3.83	< 0.0001	19.3;25.7	21.50 ± 1.45	< 0.0001
Codons 8/9 (+G)/ W	16	3.4; 3.9	3.73 ± 0.12	< 0.0001	59.6; 67.6	63.20 ± 2.34	< 0.0001	17.9; 21.1	19.04 ± 0.90	< 0.0001
IVS-I-110 (G>A)/ W	16	3.1; 3.9	3.72 ± 0.21	< 0.0001	57.7; 69.5	64.53 ± 3.49	< 0.0001	13.8; 21.8	19.46 ± 2.06	< 0.0001
–101 (C > T)/W	8	3.4; 3.9	3.68 ± 0.20	< 0.0001	72.8; 88.0	79.68 ± 4.78	0.935	23.0; 27.7	26.11 ± 1.77	0.677
IVS-I-128 (T>G)/W	8	3.5; 3.9	3.67 ± 0.15	< 0.0001	68.0; 77.9	71.63 ± 3.52	0.870	20.4; 25.4	22.51 ± 1.58	0.806
Codons 36/37 (–T)/W	7	3.2; 3.8	3.62 ± 0.20	0.001	62.0; 70.4	66.24 ± 3.42	0.005	19.1; 22.0	20.67 ± 1.05	0.007
IVS-I-1 (G>A)/ W	4	3.7; 3.9	3.82 ± 0.09	< 0.0001	61.3; 62.9	62.12 ± 0.71	0.001	18.0; 19.8	19.02 ± 0.75	0.001
Codons 82/83 (–G)/ W	4	3.2; 3.8	3.62 ± 0.28	0.078	53.1; 64.5	59.15 ± 4.77	< 0.0001	16.2; 19.8	18.35 ± 1.60	< 0.0001
Coexistence of α- and β-thalassemia genotypes	5	3.2; 3.7	3.40 ± 0.21	0.980	68.1; 79.0	72.9 ± 4.18	1.000	20.1; 25.4	22.62 ± 2.22	0.985