Skip to main content

Table 4 Comparison of mean values of Hb A2, MCV and MCH in α-thalassemia genotypes (as a single group) with those in common β-thalassemia genotypes identified in this study

From: Problem of borderline hemoglobin A2 levels in an Iranian population with a high prevalence of α- and β-thalassemia carriers

Genotype n Hb A2 MCV MCH
Min; max Mean p value Min; max Mean p value Min; max Mean p value
α-Thalassemia genotypes 127 3.1; 3.9 3.23 ± 0.18   59.9; 102.5 75.87 ± 5.69   18.3; 32.5 24.22 ± 2.31  
IVS-II-1 (G>A)/ W 36 3.1; 3.9 3.70 ± 0.23  < 0.0001 58.6; 76.4 64.73 ± 4.40  < 0.0001 17.0; 24.7 19.86 ± 1.70  < 0.0001
IVS-I-6 (T>C)/ W 30 3.1; 3.9 3.71 ± 0.22  < 0.0001 63.0; 78.2 69.28 ± 3.83  < 0.0001 19.3;25.7 21.50 ± 1.45  < 0.0001
Codons 8/9 (+G)/ W 16 3.4; 3.9 3.73 ± 0.12  < 0.0001 59.6; 67.6 63.20 ± 2.34  < 0.0001 17.9; 21.1 19.04 ± 0.90  < 0.0001
IVS-I-110 (G>A)/ W 16 3.1; 3.9 3.72 ± 0.21  < 0.0001 57.7; 69.5 64.53 ± 3.49  < 0.0001 13.8; 21.8 19.46 ± 2.06  < 0.0001
–101 (C > T)/W 8 3.4; 3.9 3.68 ± 0.20  < 0.0001 72.8; 88.0 79.68 ± 4.78 0.935 23.0; 27.7 26.11 ± 1.77 0.677
IVS-I-128 (T>G)/W 8 3.5; 3.9 3.67 ± 0.15  < 0.0001 68.0; 77.9 71.63 ± 3.52 0.870 20.4; 25.4 22.51 ± 1.58 0.806
Codons 36/37 (–T)/W 7 3.2; 3.8 3.62 ± 0.20 0.001 62.0; 70.4 66.24 ± 3.42 0.005 19.1; 22.0 20.67 ± 1.05 0.007
IVS-I-1 (G>A)/ W 4 3.7; 3.9 3.82 ± 0.09  < 0.0001 61.3; 62.9 62.12 ± 0.71 0.001 18.0; 19.8 19.02 ± 0.75 0.001
Codons 82/83 (–G)/ W 4 3.2; 3.8 3.62 ± 0.28 0.078 53.1; 64.5 59.15 ± 4.77  < 0.0001 16.2; 19.8 18.35 ± 1.60  < 0.0001
Coexistence of α- and β-thalassemia genotypes 5 3.2; 3.7 3.40 ± 0.21 0.980 68.1; 79.0 72.9 ± 4.18 1.000 20.1; 25.4 22.62 ± 2.22 0.985