Problem of borderline hemoglobin A2 levels in an Iranian population with a high prevalence of α- and β-thalassemia carriers

Egyptian Journal of Medical Human Genetics

Table 5 Comparison of mean values of Hb A₂, MCV and MCH in β-thalassemia genotypes (as a single group) with those in α-thalassemia genotypes identified in this study

Genotype	n	Hb A₂			MCV			MCH
Genotype	n	Min; max	Mean	p value	Min; max	Mean	p value	Min; max	Mean	p value
β-Thalassemia genotypes	150	3.1; 3.9	3.71 ± 0.20		51.0; 88.0	66.66 ± 5.82		13.0; 27.7	20.54 ± 2.42
αα/-α	69	3.1; 3.8	3.21 ± 0.16	< 0.0001	67.0; 102.5	78.27 ± 4.67	< 0.0001	20.8; 32.5	25.32 ± 1.64	< 0.0001
-α/-α	18	3.1; 3.9	3.28 ± 0.25	< 0.0001	63.0; 74.0	69.22 ± 3.10	0.645	19.1;23.9	21.25 ± 1.37	0.896
αα/–	4	3.1; 3.5	3.25 ± 0.19	< 0.0001	66.9; 72.4	68.97 ± 2.60	0.991	20.6; 21.9	21.37 ± 0.55	0.993
αα/α^NDα or αα/αα^ND	36	3.1; 3.9	3.23 ± 0.19	< 0.0001	59.9; 87.1	75.35 ± 5.39	< 0.0001	18.3; 27.6	23.91 ± 2.25	< 0.0001
Coexistence of α- and β-thalassemia genotypes	5	3.2; 3.7	3.40 ± 0.21	0.047	68.1; 79.0	72.9 ± 4.18	0.372	20.1; 25.4	22.62 ± 2.22	0.566