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Table 5 Comparison of mean values of Hb A2, MCV and MCH in β-thalassemia genotypes (as a single group) with those in α-thalassemia genotypes identified in this study

From: Problem of borderline hemoglobin A2 levels in an Iranian population with a high prevalence of α- and β-thalassemia carriers

Genotype n Hb A2 MCV MCH
Min; max Mean p value Min; max Mean p value Min; max Mean p value
β-Thalassemia genotypes 150 3.1; 3.9 3.71 ± 0.20   51.0; 88.0 66.66 ± 5.82   13.0; 27.7 20.54 ± 2.42  
αα/-α 69 3.1; 3.8 3.21 ± 0.16  < 0.0001 67.0; 102.5 78.27 ± 4.67  < 0.0001 20.8; 32.5 25.32 ± 1.64  < 0.0001
-α/-α 18 3.1; 3.9 3.28 ± 0.25  < 0.0001 63.0; 74.0 69.22 ± 3.10 0.645 19.1;23.9 21.25 ± 1.37 0.896
αα/– 4 3.1; 3.5 3.25 ± 0.19  < 0.0001 66.9; 72.4 68.97 ± 2.60 0.991 20.6; 21.9 21.37 ± 0.55 0.993
αα/αNDα or αα/ααND 36 3.1; 3.9 3.23 ± 0.19  < 0.0001 59.9; 87.1 75.35 ± 5.39  < 0.0001 18.3; 27.6 23.91 ± 2.25  < 0.0001
Coexistence of α- and β-thalassemia genotypes 5 3.2; 3.7 3.40 ± 0.21 0.047 68.1; 79.0 72.9 ± 4.18 0.372 20.1; 25.4 22.62 ± 2.22 0.566
  1. ND, non-deletional