Table 2 Distribution of genotypes and allele frequency in CDKN2A/B gene polymorphism (rs10811661) for T2DM and control subjects
rs10811661 (T/C) | T2DM n = 400 | Control n = 400 | Unadjusted OR (95% CI) | P value | Adjusted OR. (95% CI) | P value |
|---|---|---|---|---|---|---|
Co-dominant | ||||||
CC (reference) | 23 (6%) | 44 (11%) | ||||
TT | 249 (62%) | 188 (47%) | 2.53 (1.47–4.34) | 0.0007 | 2.51 (1.47–4.24) | 0.004 |
TC | 128 (32%) | 168 (42%) | 1.45 (0.83–2.53) | 0.18 | 1.14 (0.77–2.62) | 0.132 |
Dominant | ||||||
CC (reference) | 23 | 44 | ||||
TT + TC | 377 | 356 | 2.02 (1.19–3.42) | 0.008 | 1.99 (1.11–3.25) | 0.002 |
Recessive | ||||||
TC + CC (reference) | 151 | 212 | ||||
TT | 249 | 188 | 1.86 (1.40––2.46) | < 0.0001 | 1.918 (1.48–2.55) | < 0.0001 |
Additive | ||||||
CC (reference) | 23 | 44 | ||||
2(TT) + TC | 626 | 544 | 2.2 (1.31–3.69) | 0.002 | ||
Risk allele frequency (T) | ||||||
C | 174 (22%) | 256 (32%) | ||||
T | 626 (78%) | 544 (68%) | 1.69 (1.35–2.11) | < 0.0001 | ||