Table 3 Distribution of genotypes and allele frequency in CDKN2A/B gene polymorphism (rs2383208) for T2DM and control subjects
rs2383208 (A/G) | T2DM n = 400 | Control n = 400 | Unadjusted OR. (95% CI) | P value | Adjusted OR (95% CI) | P value |
|---|---|---|---|---|---|---|
Co-dominant | ||||||
GG (reference) | 26 (6%) | 35 (9%) | ||||
AA | 223 (56%) | 203 (51%) | 1.47 (0.86–2.54) | 0.15 | 1.51 (0.92–2.94) | 0.11 |
AG | 151 (38%) | 162 (40%) | 1.25 (0.72—2.18) | 0.42 | 1.14 (0.68–2.02) | 0.632 |
Dominant | ||||||
GG (reference) | 26 | 35 | ||||
AA + AG | 374 | 365 | 1.37 (0.81–2.33) | 0.23 | 1.19 (0.72–1.95) | 0.455 |
Recessive | ||||||
GG + AG (reference) | 177 | 197 | ||||
AA | 223 | 203 | 1.22 (0.92—1.61) | 0.15 | 0.998 (0.78—1.26) | 0.661 |
Additive | ||||||
GG | 26 | 35 | ||||
2(AA) + AG | 597 | 568 | 1.41 (0.84–2.38) | 0.19 | ||
Risk allele frequency (A) | ||||||
G | 203 (25%) | 232 (29%) | ||||
A | 597 (75%) | 568 (71%) | 1.2 (0.96–1.49) | 0.1 | ||